ورزش و علوم زیست حرکتی

ورزش و علوم زیست حرکتی

مقایسه تاثیر تمرینات تناوبی با شدت بالا و تمرینات مقاومتی شدید بر برخی عوامل خطرزای قلبی عروقی، شاخص آتروژنیک و آنزیم های کبدی در مردان دارای اضافه وزن و چاق

نوع مقاله : مقاله پژوهشی

نویسندگان
1 استادیار، گروه تربیت بدنی و علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه نیشابور، نیشابور، ایران
2 استادیار، گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه زابل، زابل، ایران
چکیده
مقدمه و هدف: فعالیت بدنی منظم برای پیشگیری از بیماری‌های قلبی‌عروقی در افراد دارای اضافه وزن و چاق توصیه می‌شود. هدف مطالعه حاضر مقایسه تاثیر تمرین تناوبی با شدت بالا (HIIT) و مقاومتی شدید بر برخی عوامل خطرزای قلبی عروقی، شاخص آتروژنیک و آنزیم‌های کبدی در مردان دارای اضافه وزن و چاق بود.
مواد ‌و ‌روش‌ها: در این مطالعه نیمه‌‌تجربی، 31 مرد دارای اضافه وزن و چاق به صورت تصادفی در سه گروه تمرین HIIT (11 نفر)، تمرین مقاومتی شدید (10 نفر) و کنترل (10 نفر) تقسیم شدند. آزمودنی‌ها در گروه HIIT با شدت 90-85 درصد ضربان‌قلب‌ذخیره و در گروه تمرینات مقاومتی با شدت 85-80 درصد یک‌تکرار بیشینه، 3 جلسه در هفته به مدت 9 هفته به اجرای تمرینات پرداختند. قبل و پس از مداخله، جهت اندازه‌گیری نیم‌رخ لیپیدی، آنزیم‌های کبدی و محاسبه شاخص‌های آتروژنیک از آزمودنی‌ها نمونه‌های خونی به عمل آمد. از آزمون تحلیل کوواریانس جهت تجزیه و تحلیل داده‌ها استفاده شد.
یافته‌ها: درگروه HIIT کلسترول‌تام، تری‌گلیسرید، شاخص آتروژنیک پلاسما، CRI-I، CRI-II، ضریب آتروژنیک و ALT نسبت به گروه کنترل به طور‌معنی‌داری کاهش یافت (0.05>P). HDL در گروه HIIT در مقایسه با پیش آزمون به‌طورمعنی‌داری افزایش یافت. در گروه مقاومتی شدید کلسترول ‌تام، تری‌گلیسرید، شاخص آتروژنیک پلاسما، CRI-I و ضریب آتروژنیک نسبت به گروه کنترل به طور‌معنی‌داری کاهش یافت (0.05>P). تفاوت معنی‌داری بین دو گروه HIIT و مقاومتی مشاهده نشد (0.05<P).
بحث ‌ونتیجه گیری: نتایج مطالعه حاضر پیشنهاد می‌کند که هردو تمرینات HIIT و مقاومتی شدید در بهبود عوامل خطرزای قلبی‌عروقی موثر می‌باشند اما به نظر می‌رسد میزان بهبود عوامل خطرزای قلبی‌عروقی، آتروژنیک و آنزیم‌های کبدی در تمرینات HIIT بیشتر باشد.
کلیدواژه‌ها

عنوان مقاله English

Comparison of the effect of high-intensity interval training and intense resistance training on some cardiovascular risk factors, atherogenic index and liver enzymes in overweight and obese men

نویسندگان English

mehdi zarei 1
Javad Nakhzari Khodakheir 2
1 Assistant professor, Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, University of Neyshabur, Neyshabur, Iran
2 Assistant professor, Department of physical education and Sport Sciences, school of Human Sciences, University of Zabol, Zabol, Iran
چکیده English

Introduction and Purpose: Regular physical activity is recommended for the prevention of cardiovascular diseases in overweight and obese people. The aim of this study was to compare the effect of high intensity interval training (HIIT) and intense resistance on some cardiovascular risk factors, atherogenic index and liver enzymes in overweight and obese men.
Materials and Methods: In this semi-experimental study, 31 overweight and obese men were randomly divided into three groups: HIIT training (n=11), intense resistance training (n=10) and control (n=10). Subjects in the HIIT group performed exercises with an intensity of 85-90% heart rate reserve and in the resistance training group with an intensity of 80-85% one repetition maximum, 3 sessions per week for 9 weeks. Before and after the intervention, blood samples were taken from the subjects to measure the lipid profile, liver enzymes and calculate atherogenic indices. Analysis of covariance test was used to analyze the data.
Results: In the HIIT group, total cholesterol, triglycerides, plasma atherogenic index, CRI-I, CRI-II, atherogenic coefficient and ALT decreased significantly compared to the control group (P<0.05). HDL increased significantly in the HIIT group compared to the pre-test. In the severe resistance group, total cholesterol, triglyceride, plasma atherogenic index, CRI-I and atherogenic coefficient  decreased significantly compared to the control group (P<0.05). No significant difference was observed between HIIT and resistance groups (P>0.05).
Discussion and conclusion: The results of the present study suggest that both HIIT and intense resistance training exercises are useful in improving cardiac risk factors, but it seems that the rate of improvement of cardiac risk factors, atherogenic and liver enzymes is higher in HIIT exercises.

کلیدواژه‌ها English

High-Intensity Interval Training
Resistance Training
atherogenic Index
Obesity
Moussavi Javardi MS, Madani Z, Movahedi A, Karandish M, Abbasi B. The correlation between dietary fat quality
indices and lipid profile with Atherogenic index of plasma in obese and non-obese volunteers: a cross-sectional descriptiveanalytic case-control study. Lipids in Health and Disease. 2020;19:1-9 .doi: 10.1186/s12944-020-01387-4
2. Lopez-Jimenez F, Almahmeed W, Bays H, Cuevas A, Di Angelantonio E, le Roux CW, et al. Obesity and cardiovascular
disease: mechanistic insights and management strategies. A joint position paper by the World Heart Federation and World
Obesity Federation. European Journal of Preventive Cardiology. 2022;29(17):2218-37 .doi: 10.1093/eurjpc/zwac187
3. Teo KK, Rafiq T. Cardiovascular risk factors and prevention: a perspective from developing countries. Canadian Journal
of Cardiology .2021 ;37(5):733-43. doi: 10.1016/j.cjca.2021.02.009
4. Vekic J, Stefanovic A, Zeljkovic A. Obesity and dyslipidemia: A review of current evidence. Current Obesity Reports.
2023;12(3):207-22 .doi: 10.1007/s13679-023-00518-z
5. Zhang T, Chen J, Tang X, Luo Q, Xu D, Yu B. Interaction between adipocytes and high-density lipoprotein: new insights
into the mechanism of obesity-induced dyslipidemia and atherosclerosis. Lipids in Health and Disease. 2019;18:1-11 .doi:
10.1186/s12944-019-1170-9
تاثیر تمرینات تناوبی و مقاومتی بر عوامل خطر قلبی عروقی و آنزیمهای کبدی
)40( ورزش و علوم زیست حرکتی سال پانزدهم/ شماره /2 پیاپی /30 پاییز و زمستان 1402
6. Khosravi A, Sadeghi M, Farsani ES, Danesh M, Heshmat-Ghahdarijani K, Roohafza H, et al. Atherogenic index of
plasma: a valuable novel index to distinguish patients with unstable atherogenic plaques. Journal of Research in Medical
Sciences: The Official Journal of Isfahan University of Medical Sciences. 2022;27 .doi: 10.4103/jrms.jrms_590_21. [In
Persian]
7. Kaneko H, Itoh H, Kiriyama H, Kamon T, Fujiu K, Morita K, et al. Lipid profile and subsequent cardiovascular disease
among young adults aged< 50 years. The American Journal of Cardiology. 2021;142:59-65 .doi: 10.1186/s12944-019-1170-9
9. Çelik E, Çora AR, Karadem KB. The effect of untraditional lipid parameters in the development of coronary artery
disease: Atherogenic index of plasma, Atherogenic coefficient and lipoprotein combined index. Journal of the Saudi Heart
Association. 2021;33(3):244 .doi: 10.37616/2212-5043.1266
10. Sujatha R, Kavitha S. Atherogenic indices in stroke patients: A retrospective study. Iranian journal of neurology.
2017;16(2):78 .https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526781/
10. Gaggini M, Gorini F, Vassalle C. Lipids in atherosclerosis: pathophysiology and the role of calculated lipid indices in
assessing Cardiovascular Risk in patients with hyperlipidemia. International Journal of Molecular Sciences. 2022;24(1):75 .
doi: 10.3390/ijms24010075
11. Salcedo-Cifuentes M, Belalcazar S, Acosta EY, Medina-Murillo JJ. Conventional biomarkers for cardiovascular risks
and their correlation with the castelli risk index-indices and TG/HDL-c. Archivos de Medicina (Manizales). 2020;20(1):11-
22 .doi: 10.30554/archmed.20.1.3534.2020
12. Abid H, Abid Z, Abid S. Atherogenic indices in clinical practice and biomedical research: a short review. Baghdad
Journal of Biochemistry and Applied Biological Sciences. 2021;2(02):60-70 .doi: https://doi.org/10.47419/bjbabs.v2i02.52
13. Ferrannini G, Rosenthal N, Hansen MK, Ferrannini E. Liver function markers predict cardiovascular and renal outcomes
in the CANVAS Program. Cardiovascular Diabetology. 2022;21(1):127 .doi: 10.1186/s12933-022-01558-w
14. Higashitani M, Mizuno A, Kimura T, Shimbo T, Yamamoto K, Tokioka S, et al. Low Aspartate Aminotransferase
(AST)/Alanine Aminotransferase (ALT) Ratio Associated with Increased Cardiovascular Disease and its Risk Factors in
Healthy Japanese Population. Journal of Gastrointestinal & Liver Diseases. 2022;31(4). doi: 10.15403/jgld-4446
15. Ndrepepa G. Aspartate aminotransferase and cardiovascular disease—a narrative review. Journal of Laboratory and
Precision Medicine. 2021;6(6). doi: 10.21037/jlpm-20-93
16. Bellicha A, van Baak MA, Battista F, Beaulieu K, Blundell JE, Busetto L, et al. Effect of exercise training on weight
loss, body composition changes, and weight maintenance in adults with overweight or obesity: An overview of 12 systematic
reviews and 149 studies. Obesity Reviews. 2021;22:e13256 .doi: 10.1111/obr.13256
17. Valenzuela PL, Ruilope LM, Santos-Lozano A, Wilhelm M, Kränkel N, Fiuza-Luces C, et al. Exercise benefits in
cardiovascular diseases: from mechanisms to clinical implementation. European Heart Journal. 2023;44(21):1874-89 .doi:
10.1093/eurheartj/ehad170
18. McLeod KA, Jones MD, Thom JM, Parmenter BJ. Resistance training and high-intensity interval training improve
cardiometabolic health in high risk older adults: a systematic review and meta-anaylsis. International journal of sports
medicine. 2021:206-18 .doi: 10.1055/a-1560-6183
19. Amaro-Gahete FJ, De-la-O A, Jurado-Fasoli L, Dote-Montero M, Gutierrez A, Ruiz JR, et al. Changes in physical
fitness after 12 weeks of structured concurrent exercise training, high intensity interval training, or whole-body
electromyostimulation training in sedentary middle-aged adults: a randomized controlled trial. Frontiers in physiology.
2019;10:451 .doi: 10.3389/fphys.2019.00451
20. Atashak S, Ahmadi-Zad A. Effect of eight weeks of resistance exercise on new biomarkers of cardiovascular disease in
obese adult males. Feyz Medical Sciences Journal (FEYZ). 2017;21(3):256-64 .http://feyz.kaums.ac.ir/article-1-3022-
en.html. [In Persian]
21. Liu Y, Lee D-C, Li Y, Zhu W, Zhang R, Sui X, et al. Associations of resistance exercise with cardiovascular disease
morbidity and mortality. Medicine and science in sports and exercise. 2019;51(3):499 .doi:
10.1249/MSS.0000000000001822
22. Liang M, Pan Y, Zhong T, Zeng Y, Cheng AS. Effects of aerobic, resistance, and combined exercise on metabolic
syndrome parameters and cardiovascular risk factors: A systematic review and network meta-analysis. Reviews in
cardiovascular medicine. 2021;22(4):1523-33 .doi: 10.31083/j.rcm2204156
23. Schroeder EC, Franke WD, Sharp RL, Lee D-c. Comparative effectiveness of aerobic, resistance, and combined training
on cardiovascular disease risk factors: A randomized controlled trial. PloS one. 2019;14(1):e0210292 .
doi:10.1371/journal.pone.0210292
24. Yao J, Meng M, Yang S, Li F, Anderson RM, Liu C, et al. Effect of aerobic and resistance exercise on liver enzyme and
blood lipids in Chinese patients with nonalcoholic fatty liver disease: a randomized controlled trial. International Journal of Clinical and Experimental Medicine. 2018;11(5):4867-74 .doi: 10.3760/cma.j.issn.1007-3418.2018.01.009
25. Haghighi AH, Hajinia M, Askari R, Abbasian S, Goldfied G. Effect of high-intensity interval training and high-intensity
resistance training on irisin and fibroblast growth factor 21 in men with overweight and obesity. Canadian Journal of
Physiology and Pharmacology. 2022;100(9):937-44 .doi: 10.1139/cjpp-2021-0712
26. Dianatinasab A, Koroni R, Bahramian M, Bagheri-Hosseinabadi Z, Vaismoradi M, Fararouei M, et al. The effects of
aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with
metabolic syndrome: A randomized controlled trial. Journal of Exercise Science & Fitness. 2020;18(3):168-76 .doi:
10.1016/j.jesf.2020.06.004
27. Mohammadi HR, Khoshnam MS, Khoshnam E. Effects of different modes of exercise training on body composition and
risk factors for cardiovascular disease in middle-aged men. International journal of preventive medicine. 2018;9.doi:
10.4103/ijpvm.IJPVM_209_16
28. Karvonen MJ. The effects of training on heart rate; a longitudinal study. Annales Medicinae Experimentalis et Biologiae
Fenniae. 1957;35:307-15 .https://pubmed.ncbi.nlm.nih.gov/13470504/
29. Brzycki M. Strength testing—predicting a one-rep max from reps-to-fatigue. Journal of physical education, recreation
& dance. 1993;64(1):88-90 .doi.org/10.1080/07303084.1993.10606684
30. Jackson AS, Pollock ML. Practical assessment of body composition. The Physician and sportsmedicine. 1985;13(5):76-
90 .doi: 10.1080/00913847.1985.11708790
31. Ahmadi M, Abbassi Daloii A, Shadmehri S, Agghaei Bahmanbeglu N. Compare the effect of eight weeks aerobic and
resistance training on Oxidant, antioxidant status and lipid profile in obese girls. Journal of Sport and Exercise Physiology.
2019;11(1):139-52. https://joeppa.sbu.ac.ir/article_98912.html?lang=fa.[In Persian]
32. Hajinia M, Haghighi AH, Askari R. The effect of high-intensity interval training and high-intensity resistance training
on the Lipid profile and body composition in overweight and obese men. Journal of Torbat Heydariyeh University of
Medical Sciences. 2020;8(3):61-74 .http://jms.thums.ac.ir/article-1-849-en.html[In Persian]
33. Keihaniyan A, Arazi H, Kargarfard M. The Effect of eight-week resistance and aerobic training on lipid profile and
sserum levels of hepatokine HFREP1 in obese men with type 2 diabetes. Sport Physiology. 2018;10(40):85-98 .
doi.org/10.22089/spj.2018.5891.1773. [In Persian]
34. Saghi F, Hakak Dokht E, Moazzami M. The compersion of aerobic training and resistance training on plasma omentin
and insulin resistance and lipid profile in obese postmenopausal women. Metabolism and Exercise. 2017;7(2):169-82 .
doi.org/10.22124/jme.2017.3382. [In Persian]
35. Mann S, Beedie C, Jimenez A. Differential effects of aerobic exercise, resistance training and combined exercise
modalities on cholesterol and the lipid profile: review, synthesis and recommendations. Sports medicine. 2014;44:211-21 .
doi: 10.1007/s40279-013-0110-5
36. Jamka M, Makarewicz-Bukowska A, Bokayeva K, Śmidowicz A, Geltz J, Kokot M, et al. Comparison of the effect of
Endurance, Strength and Endurance-Strength Training on Glucose and Insulin Homeostasis and the Lipid Profile of
Overweight and obese subjects: a systematic review and meta-analysis. International Journal of Environmental Research and
Public Health. 2022;19(22):14928 .doi: 10.3390/ijerph192214928
37. Buzdagli Y, Tekin A, Eyipinar C, Öget F, Siktar E. The effect of different types of exercise on blood lipid profiles: A
meta-analysis of randomized controlled studies. Science & Sports. 2022;37(8):675-87 .doi.org/10.1016/j.scispo.2022.07.005
38. Pashaei Z, Jafari A, Alivand M. The Effect of High Intensity Interval Training on Lipid Profile and Glucose
Homeostasis in Overweight/Obese Middle-Aged Women. Journal of Applied Health Studies in Sport Physiology.
2020;6(2):56-64 .doi: 10.22049/JASSP.2020.14018. [In Persian]
39. Banitalebi E, Rahimi A, Faramarzi M, Ghahfarrokhi MM. The effects of elastic resistance band training and green
coffee bean extract supplement on novel combined indices of cardiometabolic risk in obese women. Research in
Pharmaceutical Sciences. 2019;14(5):414 .doi: 10.4103/1735-5362.268202
40. Dadban Shahamat M, Arab Koohsar R. Effects of four weeks of high-intensity intermittent training and continuous
walking on atherogenic indices of obese middle-aged men. Medical Laboratory Journal. 2021;15(2):42-7 .doi:
10.29252/mlj.15.2.42
41. Paahoo A, Tadibi V, Behpoor N. Effectiveness of continuous aerobic versus high-intensity interval training on
atherosclerotic and inflammatory markers in boys with overweight/obesity. Pediatric exercise science. 2021;33(3):132-8 .
doi: 10.1123/pes.2020-0138
42. Yuan X, Hu J. Effects of high-intensity interval training on physical fitness and body composition of obese college
students. Revista Brasileira de Medicina do Esporte. 2023;29:e2023_0050 .doi.org/10.1590/1517-8692202329012023
43. Bachi AL, Barros MP, Vieira RP, Rocha GA, de Andrade P, Victorino AB, et al. Combined exercise training performed
by elderly women reduces redox indexes and proinflammatory cytokines related to atherogenesis. Oxidative Medicine and
Cellular Longevity. 2019;2019 .doi: 10.1155/2019/6469213
44. Ratajczak M, Skrypnik D, Bogdański P, Mądry E, Walkowiak J, Szulińska M, et al. Effects of endurance and
endurance–strength training on endothelial function in women with obesity: A randomized trial. International journal of
environmental research and public health. 2019;16(21):4291 .doi: 10.3390/ijerph16214291
45. Ebrahimi_Torkamani B, Siahkoohian M, Fasihi A. Comparison the effect of three aerobic, resistance and combined
(aerobic+ resistance) training methods on serum levels of Irizin, Atherogenic Index of Plasma and some cardiovascular risk
factors in Inactive Overweight Men. New Approaches in Exercise Physiology. 2022;4(8):193-212 .doi:
10.22054/NASS.2023.73042.1130
46. Rezaei M, Siahkouhian M, Seifi-Skishahr F, Ebrahimi-Torkamani B, Hemati S. Comparison of concurrent aerobic,
resistance and combination (aerobic+ resistance) training on serum levels of leptin, atherogenic index of plasma and
cardiovascular risk factors in obese inactive student girls. Pajouhan Scientific Journal. 2022;20(4):194-205 .doi:
10.52547/psj.20.4.194. [In Persian]
47. Rajabi S, Askari R, Haghighi A, Razavianzadeh N. The effect of resistance-aerobic interval training on the fatty liver
grade, liver dimensions, and liver enzymes in obese or overweight women with fatty liver. Community Health Journal.
2021;14(4):65-74 .https://chj.rums.ac.ir/article_125925.html. [In Persian]
48. Galedari M, Kaki A. The effect of 12 weeks high intensity interval training and resistance training on liver fat, liver
enzymes and insulin resistance in men with nonalcoholic fatty liver. Jundishapur Scientific Medical Journal. 2017;16(5):493-
503 .doi: 10.22118/JSMJ.2017.53990. [In Persian]
49. Nikroo H, Hosseini SRA, Fathi M, Sardar MA, Khazaei M. The effect of aerobic, resistance, and combined training on
PPAR-α, SIRT1 gene expression, and insulin resistance in high-fat diet-induced NAFLD male rats. Physiology & Behavior.
2020;227:113149 .doi: 10.1016/j.physbeh.2020.113149
50. Shamsoddini A, Sobhani V, Chehreh MEG, Alavian SM, Zaree A. Effect of aerobic and resistance exercise training on
liver enzymes and hepatic fat in Iranian men with nonalcoholic fatty liver disease. Hepatitis monthly. 2015;15(10). doi:
10.5812/hepatmon.31434.
51. Hong F, Liu Y, Lebaka VR, Mohammed A, Ye W, Chen B, et al. Effect of exercise training on serum transaminases in
patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis. Frontiers in Physiology .
2022;13:894044 .doi: 10.3389/fphys.2022.894044
52. Silva M, Santos F, Lagares L, Macedo R, Takanami L, Almeida L, et al. Physical exercise and changes in AST/ALT
rates in non-alcoholic fatty liver disease: a systematic review of clinical trials. Preprints. 2023 .doi:
10.20944/preprints202304.0318.v1
53. Słomko J, Zalewska M, Niemiro W, Kujawski S, Słupski M, Januszko-Giergielewicz B, et al. Evidence-based aerobic
exercise training in metabolic-associated fatty liver disease: systematic review with meta-analysis. Journal of Clinical
Medicine. 2021;10(8):1659 .doi: 10.3390/jcm10081659
54. Hejazi K, Hackett D .Effect of exercise on liver function and insulin resistance markers in patients with non-alcoholic
fatty liver disease: a systematic review and meta-analysis of randomized controlled trials. Journal of Clinical Medicine.
2023;12(8):3011 .doi: 10.3390/jcm12083011

  • تاریخ دریافت 10 مهر 1402
  • تاریخ بازنگری 22 مهر 1402
  • تاریخ پذیرش 25 آبان 1402