Backgrounds and Objectives: The risk of cardiovascular diseases especially Atherosclerosis in diabetes individual is twice diabetes non individuals. VON WILLBRAND FACTOR is one of the coagulation factors that by increasing blood sugar and insulin resistance were considered as a major case of endothelial dis function and development of Atherosclerosis. The purpose of this study is researching of the effect of aerobic training on vascular biochemical marker and insulin resistance index in type 2 diabetes patients.
Methods and materials: 16 women who are stricken to type 2 diabetes was set accidentally at two aerobic groups 11 person and control groups 5 person. Aerobic groups have aerobic training 8 weeks, 3days/weeks at60% HRr. Blood samples prepared for measuring levels VWF and insulin at 2 stages, pretest and posttest after 10-12 hours breakfast. Statistical analysis was done by independent t- tests and Pearson correlation.
Results: there was improvement of insulin sensitivity and decreasing weight and BMI at aerobic groups was observed and decrease levels VWF (p=0.02). Also there is a correlation between the changes of VWF and insulin resistance following aerobic training(r=0.802).
Conclusion: At the direct of improvement insulin sensitivity following eight weeks aerobic training, VWF was decreased at the individuals who have diabetes type 2.