عنوان مقاله English
Introduction: Despite the many clinical observations regarding the beneficial effects of hypoxia, the mechanism of its effect on the angiogenesis of the cardiac tissue has not yet been studied. However, the aim of this study to investigate. The effects of aerobic training and hypoxia on expression angiogenic factors in cardiac male wistar rats.
Materials and Methods: In the current experimental study, forty male Wistar rats weighing 220±20 gr were randomly divided into four groups; normal control (NC), hypoxia (H), Hypoxia + training (HT) and training groups. Hypoxia group exposed to chronic intermittent hypoxia (PiO2≈106 mmHg, simulated altitude ≈ 3400 m, 14% oxygen for 8 weeks). And exercise group ran on a treadmill for 8weeks, 3 session/ week. (HT) Group, after exercise, during the day were similar to hypoxia in the hypoxic chamber. Then, relative protein density of HIF1a, VEGF and PI3K were measured with western blot method.
Results: The result showed that intermittent hypoxia, exercise training+ hypoxia and exercise training significantly increased relative protein density of HIF1a, VEGF and PI3K compared to control group (p<0.001).also, significant increased relative protein density of VEGF in hypoxia group compared to exercise training+ hypoxia group (p<0.034). However, significant increased relative protein density of PI3K in exercise groups compared with control group (p<0.001).
Conclusion: It seems that hypoxia more induced angiogenesis signaling pathway and exercise training is potent stimulator for activity of P-I3K/Akt signaling pathway.
کلیدواژهها English
