نوع مقاله : مقاله پژوهشی
موضوعات
عنوان مقاله English
نویسندگان English
Introduction and Purpose: Follistatin, myostatin, and irisin are key proteins involved in the regulation of muscle hypertrophy and atrophy. This study aimed to compare the effects of eight weeks of high-intensity interval training (HIIT) and resistance training on serum levels of myostatin, follistatin, and irisin in young athletic and non-athletic women.
Materials and Methods: A total of 48 women aged 18 to 25, both athletic and non-athletic, were randomly assigned into four experimental groups (n=12 per group): athletic-HIIT, athletic-resistance training, non-athletic-HIIT, and non-athletic-resistance training. The participants in the training groups performed their respective exercise protocols three times per week for eight weeks. The HIIT protocol included three sets of the RAST protocol, in which each participant sprinted six 35-meter intervals at maximum speed per set. The number of sets was progressively increased: one additional set per week up to week four, and then one additional set every two weeks from week five to week eight, reaching a total of eight sets. The resistance training group performed eight resistance exercises in a circuit format during each session. In the first two weeks, exercises were performed at 65–75% of 1RM (equivalent to 10–12 repetitions), and from week three onward, intensity was increased to 80–85% of 1RM (equivalent to 4–6 repetitions). Paired t-tests and ANOVA were used to compare pre- and post-test within-group differences, and the Bonferroni test was applied for between-group comparisons. Statistical significance was set at P<0.05.
Results: In all four groups, post-test results showed an increase in the mean serum levels of follistatin and irisin and a decrease in myostatin compared to pre-test levels, with greater improvements observed in athletic participants (P<0.05). ANOVA results indicated no significant differences among the four groups in serum myostatin and follistatin levels (P>0.05). However, significant differences were found in serum irisin levels: between the athletic-resistance group and both the non-athletic-HIIT and non-athletic-resistance groups (P<0.05), as well as between the athletic-HIIT group and both non-athletic groups. A significant difference was also observed between the non-athletic-HIIT and non-athletic-resistance groups (P<0.05).
Discussion and Conclusion: It appears that eight weeks of high-intensity interval and resistance training can reduce myostatin and increase follistatin and irisin serum levels in both athletic and non-athletic young women. These improvements were more pronounced in the athletic participants.
کلیدواژهها English
36.Yan M, Audet-Walsh É, Manteghi S, Dufour CR, Walker B, Baba M, St-Pierre J, Giguère V, Pause A. Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα.Genes & Development2016;30(9):1034-46. doi: 10.1101/gad.281410.116.
