ورزش و علوم زیست حرکتی

ورزش و علوم زیست حرکتی

تاثیر تمرین تداومی و محدودیت کالری بر ایزوپروستان 8، مالون دی-آلدئید و اینترلوکین 6 رت‌های نر چاق

نوع مقاله : مقاله پژوهشی

نویسندگان
حسین امیری 1
صدیقه حسین پور دلاور 2
حسن صفی خانی 3
علی ضابط 4
مهدی بیگزاده 5
1 دانشجوی دکتری، گروه فیزیولوژی ورزشی،واحد کرمانشاه،دانشگاه آزاد اسلامی، کرمانشاه، ایران
2 استادیار، گروه فیزیولوژی ورزشی، واحد کرمانشاه، دانشگاه آزاد اسلامی، کرمانشاه، ایران
3 استادیار، گروه حرکات اصلاحی، واحد کرمانشاه، دانشگاه آزاد اسلامی، کرمانشاه، ایران
4 استادیار، گروه فیزیولوژی ورزشی، واحد کنگاور، دانشگاه آزاد اسلامی، کنگاور، ایران
5 استادیار، گروه فیزیولوژی ورزشی، واحد اسلام آباد غرب، دانشگاه آزاد اسلامی، اسلام‌آباد غرب، ایران
10.22034/sbs.2025.459679.1099
چکیده
مقدمه و هدف: افزایش التهاب ناشی از چاقی روی سیستم­ های بدن اثر می گذارد. مطالعه حاضر با هدف بررسی اثر تمرین تداومی و محدودیت کالری بر ایزوپروستان 8، مالون دی ­آلدئید و اینترلوکین 6 رت­ های نر چاق انجام شد.
مواد و روش­ ها: در این مطالعه تجربی، تعداد 24 سر رت نر به طور تصادفی در چهار گروه کنترل، تمرین، محدودیت کالری و تمرین+ محدودیت کالری تقسیم شدند. برنامه تمرین تداومی به مدت هشت هفته و شدت 24-33 متر در دقیقه با شیب 15 درصد حفظ شد و مدت زمان تمرین از 10 دقیقه در روز اول تمرین تا 60 دقیقه در روز، در هفته پنجم تمرین افزایش و تا انتهای برنامه با همین شرایط حفظ شد. گروه­ های دارای محدودیت، 50 درصد مقدار غذای مصرفی سایر گروه‌ها را دریافت کردند. از آزمون تحلیل واریانس یک‌طرفه و آزمون تعقیبی توکی در سطح معناداری 0.05 استفاده شد.
یافته­ ها: ایزوپروستان 8 در گروه‌های تمرین، محدودیت‌کالری و تمرین + محدودیت‌کالری نسبت به گروه کنترل به‌طور معناداری کاهش یافت (P˂0.05). هم‌چنین بین گروه تمرین + محدودیت‌کالری و محدودیت کالری نیز تفاوت معناداری وجود داشت. متغیرهای مالون دی ­آلدئید و اینترلوکین-6 در گروه‌های تمرین، محدودیت‌کالری و تمرین + محدودیت‌کالری نسبت به گروه کنترل به‌طور معناداری کاهش یافت (P˂0.05).
نتیجه­ گیری: هشت هفته تمرین تداومی به همراه محدودیت کالری، می‌تواند منجر به بهبود ایزوپروستان 8، مالون‌دی­آلدئید و اینترلوکین-6 شود. تمرین به همراه محدودیت‌کالری بیشتر از تمرین بدون رژیم محدودیت کالری است.




 
کلیدواژه‌ها
تمرین تداومی؛ محدودیت کالری؛ ایزوپروستان 8؛ مالون دی­
؛ ؛ ؛ ؛ آلدئید؛ اینترلوکین-6

موضوعات

عنوان مقاله English

The effect of continuous training and caloric restriction on isoprostane 8, malondialdehyde and interleukin-6 in obese male rats

نویسندگان English

hossien amiri 1
Sedigheh Hosseinpour Delavar 2
hasan safikhani 3
Ali Zabet 4
mahdi Beigzadeh 5
1 PhD Student, Department of Exercise Physiology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
2 Assistant Professor, Department of Exercise Physiology, Faculty of Litirature and Humanities, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran.
3 Assistant Professor, Department of Corrective Movements, Faculty of Litirature and Humanities, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
4 Assistant Professor, Department of Exercise Physiology, Kangavar Branch, Islamic Azad University, Kangavar, Iran
5 Assistant Professor, Department of Exercise Physiology, West Islamabad Branch, Islamic Azad University, West Islamabad, Iran
چکیده English

Introduction and Purpose: Obesity-induced inflammation affects various body systems. This study aimed to examine the effects of continuous exercise and calorie restriction on 8-isoprostane, malondialdehyde (MDA), and interleukin-6 (IL-6) in obese male rats.
Materials and methods: n this experimental study, 24 male rats were randomly assigned to four groups: control, exercise, calorie restriction, and exercise plus calorie restriction. The continuous exercise program lasted eight weeks, with an intensity of 24–33 meters per minute at a 15% incline. The duration increased from 10 minutes on the first day to 60 minutes per day by the fifth week and was maintained thereafter. The calorie-restricted groups received 50% of the food intake of the other groups. One-way ANOVA and Tukey's post-hoc test were used, with a significance level set at P<0.05.
Results: Levels of 8-isoprostane significantly decreased in the exercise, calorie restriction, and exercise plus calorie restriction groups compared to the control group (P<0.05). A significant difference was also observed between the exercise plus calorie restriction group and the calorie restriction group. MDA and IL-6 levels significantly decreased in the exercise, calorie restriction, and exercise plus calorie restriction groups compared to the control group (P<0.05).
Discussion and Conclusion: Eight weeks of continuous exercise combined with calorie restriction can improve levels of 8-isoprostane, MDA, and IL-6. The combination of exercise and calorie restriction is more effective than exercise without calorie restriction.

کلیدواژه‌ها English

Continuous exercise
Calorie restriction
8-isoprostane
Malondialdehyde
Interleukin-6
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ورزش و علوم زیست حرکتی
دوره 16، شماره 32
اسفند 1403
صفحه 83-94

  • تاریخ دریافت 07 خرداد 1403
  • تاریخ بازنگری 14 بهمن 1403
  • تاریخ پذیرش 28 بهمن 1403