ورزش و علوم زیست حرکتی

ورزش و علوم زیست حرکتی

تاثیر تمرین هوازی به همراه محدودیت کالری بر برخی شاخص‌های التهاب عروقی و اینترلوکین-1 رت‌های نر چاق

نوع مقاله : مقاله پژوهشی

نویسندگان
1 دانشجوی دکتری، گروه فیزیولوژی ورزشی، واحد کرمانشاه، دانشگاه آزاد اسلامی، کرمانشاه، ایران
2 استادیار، گروه فیزیولوژی ورزشی، دانشکده ادبیات و علوم انسانی، واحد کرمانشاه، دانشگاه آزاد اسلامی، کرمانشاه، ایران.
3 استادیار، گروه حرکات اصلاحی، دانشکده ادبیات و علوم انسانی، واحد کرمانشاه، دانشگاه آزاد اسلامی، کرمانشاه، ایران.
4 استادیار، گروه فیزیولوژی ورزشی، واحد کنگاور، دانشگاه آزاد اسلامی، کنگاور، ایران
5 استادیار، گروه فیزیولوژی ورزشی، واحد اسلام آباد غرب، دانشگاه آزاد اسلامی، اسلام‌آباد غرب، ایران.
چکیده
مقدمه و هدف:  افزایش التهاب ناشی از چاقی با سلامت عروقی مرتبط است. مطالعه حاضر با هدف بررسی اثر تمرین هوازی و محدودیت کالری بر برخی شاخص‌­های التهاب عروقی و اینترلوکین -1 رت‌­های نر چاق انجام شد.
مواد و روش­‌ها: تعداد 24 سر رت نر به طور تصادفی در چهار گروه کنترل، تمرین، محدودیت کالری و تمرین+ محدودیت کالری تقسیم شدند. برنامه تمرین هوازی به مدت هشت هفته و شدت 24 تا 33 متر در دقیقه با شیب 15 درصد حفظ شد و مدت زمان تمرین از 10 دقیقه در روز اول تمرین تا 60 دقیقه در روز، در هفته پنجم تمرین افزایش و تا انتهای برنامه با همین شرایط حفظ شد. گروه­‌های دارای محدودیت، 50 درصد مقدار غذای مصرفی سایر گروه­‌ها را دریافت کردند. غلظت ای­سلکتین، ICAM و اینترلوکین -1 به روش الایزا اندازه‌­گیری شد. از آزمون تحلیل واریانس یک‌طرفه و آزمون تعقیبی توکی در سطح معناداری P<0.05 استفاده شد.
یافته­‌ها: یافته­‌ها نشان داد که تمرین هوازی، محدودیت کالری و تمرین هوازی به همراه محدودیت کالری منجر به کاهش معنی ­دار ای­سلکتین (P=0.001)، ICAM (P=0.002) و اینترلوکین -1 (P=0.001) گردید.
بحث و نتیجه­‌گیری: هشت هفته تمرین هوازی چه به تنهایی و چه همراه با محدودیت کالری، منجر به بهبود سطوح برخی از فاکتورهای التهاب عروقی می ­شود.
کلیدواژه‌ها

عنوان مقاله English

The effect of aerobic training with calorie restriction on some indicators of vascular inflammation and interleukin 1 in obese male rats

نویسندگان English

Hossein Amiri 1
Sedigheh Hosseinpour Delavar 2
hassan safikhani 3
Ali Zabet 4
Mahdi Beigzadeh 5
1 PhD Student, Department of Exercise Physiology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
2 Assistant Professor, Department of Exercise Physiology, Faculty of Litirature and Humanities, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
3 ssistant Professor, Department of Corrective Movements, Faculty of Litirature and Humanities, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran.
4 Assistant Professor, Department of Exercise Physiology, Kangavar Branch, Islamic Azad University, Kangavar, Iran
5 Assistant Professor, Department of Exercise Physiology, West Islamabad Branch, Islamic Azad University, West Islamabad, Iran.
چکیده English

Introduction and Purpose: Increased inflammation caused by obesity is related to vascular health. The present study was conducted with the aim of investigating the effect of aerobic training and caloric restriction on some indicators of vascular inflammation and interleukin 1 in obese male rats.
Materials and Methods: Twenty-four male rats were randomly divided into four groups: control, exercise, calorie restriction, and exercise + calorie restriction. The aerobic training program was maintained for eight weeks, and the intensity was 24-33 meters per minute with a slope of 15%, and the duration of the training was from 10 minutes on the first day of training to 60 minutes per day, increasing in the fifth week of training and until the end of the program with the same conditions. Restricted groups received 50% of the amount of food consumed by other groups. The concentration of I-selectin, ICAM and interleukin-1 was measured by ELISA method. One-way analysis of variance and Tukey's post hoc test were used at a significance level of 0.05.
Results: The findings showed that aerobic training, calorie restriction and aerobic training with calorie restriction led to a significant decrease in e-selectin (P=0.001), decrease in ICAM (P=0.002) and interleukin-1 (P=0.001).
Discussion and Conclusion: Eight weeks of aerobic training without and with calorie restriction leads to improvement of some vascular inflammation factors.

کلیدواژه‌ها English

aerobic training
caloric restriction
E-selectin
ICAM and interleukin-1
Azizi F, Salehi P, Etemadi A, Zahedi-Asl S. Prevalence of metabolic syndrome in an urban population: Tehran Lipid and
Glucose Study. Diabetes Research and Clinical Practice .2003; 61:29– 37. http://doi.org/ 10.1016/s0168-8227(03)00066-4
2. Bagherzadeh Rahmani B, Shafiee N, Khanvari T, Kordi N. Investigation the effects of two long-term and short-term highintensity interval training on some inflammatory and immune indices in overweight adolescent boys. Journal of Sport and
Biomotor Sciences. 2021;25(25):38-48. [In Persian]. . http://doi.org/ 10.22034/sbs.2021.161240
3. Ghodrati Kamran, Mirzaei Bahman, Tadibi Vahid. Comparison of the chronic and acute effects of aerobic continuous and
high interval intensity training (HIIT) on vascular inflammation indices (ICAM1, E-Selectin) in sedentary overweight
men. Journal of Applied Health Studies in Sport Physiology. 2019; 6(1): 53-59 . http://doi.org/ 10.22049/jassp
.2019.26633.1264
4. Chinikar M, maddah M, Hoda S. coronary artery disease in Iranian overweight women. International journal of
cardiology .2006; 113:391-394. https://doi.org/10.1016/j.ijcard.2005.11.103
5. Shafie N, Kordi N, Gadruni K, SalehFard Z, Jung F, Heidari N. Cardiac rehabilitation in coronary artery bypass grafting
patients: Effect of eight weeks of moderate-intensity continuous training versus high-intensity interval training. Clinical
Hemorheology and Microcirculation. 2023; (Preprint):1-0. http://doi.org/ 10.3233/CH-221605
6. Kordi N, Saydi A, Karami S, Bagherzadeh-Rahmani B, Marzetti E, Jung F & et al. Ferroptosis and aerobic training in
ageing: A review. Clinical Hemorheology and Microcirculation. 2024:;(Preprint):1-20.doi: 10.3233/CH-232076
7. Golia E, Limongelli G, Natale F, Fimiani F, Maddaloni V, Pariggiano I & et al. Inflammation and cardiovascular disease:
from pathogenesis to therapeutic target. Current Atherosclerosis Reports. 2014; 16(9):43. http://doi.org/ 10.1007/s11883-
014-0435-z.
8. Kordi N, Shafiee N, Mirzaei S, Minavand K, Heidari N. The effect of continuous and interval cardiac rehabilitation
exercise training on tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6) in patients
with coronary artery bypass graft. Journal of Isfahan Medical School. 2018;36(486):737-42 .[In Persian] . http://doi.org/
10.22122/jims.v36i486.10019
9. Koh Y, Park J. Cell adhesion molecules and exercise. Journal of Inflammation Research. 2018; 11: 297–306.
http://doi.org/10.22122/jims.v36i486.10019
10. Lima Vieira RA, Nascimento de Freitas R, Pinheiro Volp AC. Adhesion molecules and chemokines: relation to
anthropometric, body composition, biochemical and dietary variables. Nutrición Hospitalaria. 2014;30(2):223.
http://doi.org/ 10.3305/nh.2014.30.2.7416
11. Hassan Ghomi M, Asjodi F, Kordi N, Iravani O, Samadi M, Salehpoor S. The Effects of Using Glutamine Supplementation
in 3 Days on Indices of Muscle Damage after Leg Press Eccentric Resistance. Journal of Medical Council of Iran. 2019;
36 (2) :101-106. http://doi.org/ 10.3390/nu13062073
12. Pontiroli AE, Pizzocri P, Koprivec D, Vedani P, Marchi M, Arcelloni C & et al. Body weight and glucose metabolism
have a different effect on circulating levels of ICAM-1, E-selectin, and endothelin-1 in humans. European journal of
endocrinology. 2004;150(2):195-200. http://doi.org/ 10.1530/eje.0.1500195
13. González IP, Madariaga EL, Avíles CR, Lozano MA, Escudero VM, Sanzana N & et al. Eighteen-week exercise and
nutritional education program did not modify the serum levels of sVCAM-1 and sCD40-L in subjects with metabolic
syndrome. Labmedicine.2010;41(4):231– 234. http://doi.org/ 10.1309/LMXK8V3R4FEPFVKK
14. Koh S, Kim T, Kang D, Kim D. Effectiveness of Regular Aerobic Exercise in Improving Vascular Stiffness in Elderly
Korean Women. Journal of Clinical Medicine. 2023 ;12(19):6119. http://doi.org/ 10.3390/jcm12196119
15. Fouladi M, Mahmoudabady M, Gholamnezhad Z, Shabab S, Niazmand S, Salmani H. Impact of Endurance Exercise
Training on Biomarkers of Aortic Endothelial Damage in Diabetic Rats. Cardiovascular Therapeutics.
2024;2024(1):6025911. http://doi.org/ 10.1155/2024/6025911
16. Rangraz MH, Hojjat S. The Effects of a Six-Week Aerobic Exercise on Serum Levels of Klotho, IL-10, IL-1, and Oxidative
Stress in Sedentary Young Women. Crescent Journal of Medical & Biological Sciences. 2023;10(2): 67-72. http://doi.org/
10.34172/cjmb.2023.11
17. Simpson RJ, Florida-James GD, Whyte GP, Guy K. The effects of intensive, moderate and downhill treadmill running on
human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (beta2 integrin) and
CD53. European Journal of Applied Physiology. 2006;97(1):109–121. http://doi.org/ 10.1007/s00421-006-0146-4
18. Brevetti G, De Caterina M, Martone VD, Ungaro B, Corrado F, Silvestro A & et al. Exercise increases soluble adhesion
molecules ICAM‐1 and VCAM‐1 in patients with intermittent claudication. Clinical hemorheology and microcirculation.
2001;24(3):193-9. http://doi.org/ PMID: 11455059
19. Jilma B, Eichler HG, Stohlawetz P, Dirnberger E, Kapiotis S, Wagner OF & et al. Effects of exercise on circulating
vascular adhesion molecules in healthy men. Immunobiology. 1997;197(5):505–512. http://doi.org/ 10.1016/S0171-
2985(97)80082-4
20. Moro T, Tinsley G, Pacelli FQ, Marcolin G, Bianco A, Paoli A. Twelve months of time-restricted eating and resistance
training improves inflammatory markers and cardiometabolic risk factors. Medicine and science in sports and exercise.
2021;53(12):2577. http://doi.org/ 10.1249/MSS.0000000000002738
21. Kordi N, Azizi M, Samadi M, Tahmasebi W. Can Methamphetamine-Induced Cardiotoxicity be Ameliorated by Aerobic
Training and Nutrition Bio-shield Superfood Supplementation in Rats After Withdrawal?. Cardiovascular Toxicology.
2024;30:1-3. http://doi.org/ 10.1007/s12012-024-09871-4
22. Saydi A, Behpoor N, Khamis Abadi F, Jung F, Kordi N. Modulation of pulmonary oxidative status in methamphetaminewithdrawn rats, comparing the effects of continuous training and NBS superfood supplementation. Clinical Hemorheology
and Microcirculation. (Preprint):1-2. http://doi.org/ 10.3233/CH-242306
23. Hashemkandi Asadi R, Arshadi S, Banaei Far A, Haji Rasouli M. The Effect of 12 Weeks of Aerobic Training with or
without Dietary Restriction on the Expression Levels of SIRT3, PGC1-α and SOD2 of Soleusmuscle in Male Rats. Iranian
Journal of Nutrition Sciences & Food Technology. 2019;14(2):21-30. http://nsft.sbmu.ac.ir/article-1-2757-en.html
24. Kordi N, Azizi M, Samadi M, Tahmasebi W. Effects of aerobic training on the expression of some pro- and anti-apoptotic
genes in the myocardium of rats after methamphetamine withdrawal. Journal of Sport and Biomotor Sciences.
2023;15(2):1-10. [In Persian]. http://doi.org/ 10.22034/sbs.2023.413006.1051
25. Pontiroli AE, Frigè F, Paganelli M, Folli F. In morbid obesity, metabolic abnormalities and adhesion molecules correlate
with visceral fat, not with subcutaneous fat: effect of weight loss through surgery. Obesity surgery. 2009 Jun;19:745-50.
http://doi.org/ 10.1007/s11695-008-9626-4
26. Soori R, Ravasi AA, Salehi M. Effect of aerobic exercise and caloric restriction on serum ICAM-1 and VCAM-1 in healthy
obese women. Journal of Sport Physiology. 2011; 3(10): 129-141. http://doi.org/10.1007/s11695-008-9626-4 26 .[In
Persian] .
27. Bagherzadeh-Rahmani B, Kordi N, Haghighi AH, Clark CC, Brazzi L, Marzetti E & et al. Eight weeks of pilates training
improves respiratory measures in people with a history of COVID-19: a preliminary study. Sports Health. 2023 ;15(5):710-
7. http://doi.org/ 10.1177/19417381221124601
28. Kasraei H, Kargaefard M, Nazarali P, Nobari H, Zare A. The effects of combined exercise with and without diet on plasma
inflammatory biomarkers and endothelial dysfunction in elderly patients with type 2 diabetes. Iranian Journal of Diabetes
and Metabolism. 2019;18(4):207-20. [In Persian]. http://ijdld.tums.ac.ir/article-1-5840-en.html
29. Bagheri MR, Banaifar A, Arshadi S, Sohayli S. The effect of intense aerobic training on ICAM-1, VCAM-1 and RAGE
expression in heart tissue in type 2 diabetes obese rats. medical journal of mashhad university of medical sciences.
2020;63(4):2529-2540. [In Persian]. http://doi.org/ 10.22038/mjms.2021.17594
30. Nørregaard LB, Wickham KA, Ehlers T, Rocha MP, Fischer M, Lundberg Slingsby MH & et al. Exercise training induces
thrombogenic benefits in recent but not late postmenopausal females. American Journal of Physiology-Heart and
Circulatory Physiology. 2023;325(2):346-61. http://doi.org/ 10.1152/ajpheart.00054.2023
31. Haghir H, Hejazi SM, Minaee S. Changes of serum intercellular adhesion molecule-1, vascular adhesion molecule-1 and
C-reactive protein in middle-aged men with heart failure after eight weeks of aerobic exercis. Journal of Shahid Sadoughi
University of Medical Sciences. 2017;24 (12):1013-23. [In Persian]. https://sid.ir/paper/36675/en
32. Shafiee N, Kordi N, Gadruni K, SalehFard Z, Jung F, Heidari N. Cardiac rehabilitation in coronary artery bypass grafting
patients: Effect of eight weeks of moderate-intensity continuous training versus high-intensity interval training. Clinical
Hemorheology and Microcirculation. 2023 ;83(3):305-14. http://doi.org/ 10.3233/CH-221605
33. Zhu S, Sun F, Li W, Cao Y, Wang C, Wang Y &et al. Apelin stimulates glucose uptake through the PI3K/Akt pathway
and improves insulin resistance in 3T3-L1 adipocytes. Molecular and Cellular Biochemistry. 2011;353(1-2):305-13.
http://doi.org/10.1007/s11010-011-0799-0
34. Meneguello MO, Rosa LF. Effects of caloric restriction and aerobic exercise in lymphocytes and macrophages of aging
rats. Revista Paulista de Educação Física. 2002;16(1):16-26. http://doi.org /10.11606/issn.2594-5904.rpef.2002.138691
35. Azizbeigi Boukani K, Atashak S, Etemad Z, Mohammad Zadeh Salamat K, Yekta Yar M. Effect of moderate-intensity
resistance exercise training on plasma antioxidant capacity and inflammation factors in healthy males. Scientific Journal
of Kurdistan University of Medical Sciences. 2013;18(4):1-7. [In Persian]. http://doi.org/ 10.1080/02640414.2014.900692
36. Dâmaso AR, da Silveira Campos RM, Caranti DA, de Piano A, Fisberg M, Foschini D, et al. Aerobic plus resistance
training was more effective in improving the visceral adiposity, metabolic profile and inflammatory markers than aerobic
training in obese adolescents. Journal of sports sciences. 2014;32(15):1435-45. http://doi.org/
10.1080/02640414.2014.900692
37. Kordi N, Saydi A, Azimi M, Mazdarani F, Gadruni K, Jung F, Karami S. Cuproptosis and physical training: A review.
Clinical Hemorheology and Microcirculation.(Preprint):1-4.doi: 10.3233/CH-242329

  • تاریخ دریافت 13 خرداد 1403
  • تاریخ بازنگری 22 شهریور 1403
  • تاریخ پذیرش 25 شهریور 1403