Wang W, Li J, Tao L, Lv L, Sun J, Zhang T, et al. MiR-205 regulates LRRK2 expression in dopamine neurons
in Parkinson's disease through methylation modification. Iranian Journal of Public Health. 2022; 51(7): 1637-
1647. https://doi.org/10.18502/ijph.v51i7.10098.
2. Belvisi D, Pellicciari R, Fabbrini A, Costanzo M, Pietracupa S, De Lucia M, et al. Risk factors of Parkinson
disease: Simultaneous assessment, interactions, and etiologic subtypes. Neurology. 2020; 95: e2500-e2508.
doi: 10.1212/WNL.0000000000010813.
3. Hardy J, Cai H, Cookson MR, Gwinn-Hardy K, Singleton A. Genetics of Parkinson's disease and
parkinsonism. Annals of Neurology. 2006;60:389–398. DOI: 10.1002/ana.21022.
4. Lesage S, Lunati A, Houot M, Romdhan SB, Clot F, Tesson C, et al. Characterization of recessive Parkinson
disease in a large multicenter study. Annals of Neurology. 2020; 88: 843–850. doi: 10.1002/ana.25787.
5. Tolosa E, Botta-Orfila T, Morato X, Calatayud C, Ferrer-Lorente R, Marti MJ, et al. MicroRNA alterations in
iPSC-derived dopaminergic neurons from Parkinson disease patients. Neurobiology of Aging. 2018; 69: 283–
291. doi: 10.1016/j.neurobiolaging.2018.05.032.
6. Alegre-Abarrategui J, Ansorge O, Esiri M, Wade-Martins R. LRRK2 is a component of granular alphasynuclein pathology in the brainstem of Parkinson's disease. Neuropathology and Applied Neurobiology, 2008;
34: 272-283. doi: 10.1111/j.1365-2990.2007.00888.x.
7. Rohani M. Genetics of Parkinson disease. Genetics in the Third Millennium. 2010; 8(1):1990-1997. [In
Persian].
8. Rui Q, Ni H, Li D, Gao R, Chen G. The Role of LRRK2 in neurodegeneration of Parkinson disease. Current
Neuropharmacology. 2018; 16(9): 1348–1357. doi: 10.2174/1570159X16666180222165418.
9. Kielb S, Kisanuki YY, Dawson E. Neuropsychological profile associated with an alpha-synuclein gene
(SNCA) duplication. Clinical Neuropsychologist. 2021; 36 (7): 1787-1798. https://doi.org/10. 1080/
13854046. 2021.1914735.
10. Vetchinova AS, Kapkaeva MR, Ivanov MV, Kutukova KA, Mudzhiri NM, Frumkina LE, et al. Mitochondrial
dysfunction in dopaminergic neurons derived from patients with LRRK2- and SNCA-associated genetic forms
of Parkinson’s disease. Current Issues in Molecular Biology. 2023; 45: 8395–8411. https://doi.org/10.3390/
cimb45100529.
11. O’Brien J, Hayder H, Zayed Y, Peng, C. Overview of microRNA biogenesis, mechanisms of actions, and
circulation. Frontiers Endocrinology. 2018; 9: 402. doi: 10.3389/fendo.2018.00402.
12. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with
antisense complementarity to lin-14. Cell. 1993; 75: 843–854. doi: 10.1016/0092-8674(93)90529-Y.
13. Hebert SS, De Strooper B. Alterations of the microRNA network cause neurodegenerative disease. Trends in
Neurosciences. 2009; 32: 199–206. doi: 10.1016/j.tins.2008.12.003.
14. Song H, Bu G. MicroRNA-205 inhibits tumor cell migration through downregulating the expression of the
LDL receptor-related protein 1. Biochemical and Biophysical Research Communications. 2009; 388: 400-405.
doi: 10.1016/j.bbrc.2009.08.020.
15.Cho HJ, Liu G, Jin SM, Parisiadou L, Xie C, Yu J, et al. MicroRNA-205 regulates the expression of Parkinson's
disease-related leucine-rich repeat kinase 2 protein. Human Molecular Genetic. 2013; 22(3): 608–620. doi:
10.1093/hmg/dds470.
16. Nies YH, Mohamad Najib NH, Lim WL, Kamaruzzaman MA, Yahaya MF, Teoh SL. MicroRNA
dysregulation in Parkinson’s disease: A narrative review. Frontiers Endocrinology. 2021; 15: https://doi.org/
10.3389/ fnins.2021. 660379.
17.Ji L, Steffens DC, Wang L. Effects of physical exercise on the aging brain across imaging modalities: a metaanalysis of neuroimaging studies in randomized controlled trials. International Journal of Geriatric
Psychiatry. 2021; 36: 1148–1157. doi: 10.1002/gps.5510 Epub 2021 Mar 5.
18. Sacheli MA, Neva JL, Lakhani B, Murray DK, Vafai N, Shahinfard E, et al. Exercise increases caudate
dopamine release and ventral striatal activation in Parkinson’s disease. Movement Disorders. 2019; 34: 1891–
1900. doi: 10.1002/mds.27865 Epub 2019 Oct 4.
19. Winner B, Melrose HL, Zhao C, Hinkle KM, Yue M, Kent C, et al. Adult neurogenesis and neurite outgrowth
are impaired in LRRK2 G2019S mice. Neurobiology of Disease. 2011; 41(3): 706–716. doi: 10.1016/j.nbd.
2010.12.008.
20. Schootemeijer S, Coker D, Shelton JF, Chanoff E, Rowbotham HM, Darweesh SKL, et al. Exercise
knowledge, barriers and motivators among LRRK2 G2019S mutation carriers. Parkinsonism & Related
Disorders. 2023; 113: 105497. doi: 10.1016/j.parkreldis.2023.105497.
21. Olson J, Sheean P, Matthews L, Chitambar CR, Banerjee A, Visotcky A, et al. Circulating miRNAs as early
indicators of diet and physical activity response in women with metastatic breast cancer. Future Science OA.
2021; 7(4): FSO694. doi: 10.2144/fsoa-2020-0208.
22.Rezaei Z, Shakerian S, Nikbakht M. Comparison of the effect of 10 weeks of high intensity interval training
with continuous endurance training on MiR-205 and VEGF gene expression in mice with breast cancer.
Journal of Applied Health Studies in Sport Physiology. 2019; 6(1): 37-44. [In Persian] http://dx.doi.org/
10.22049/jassp.2019.26611.1258.
23. Zahraei H, Mogharnasi M, Afzalpour ME, Fanaei H. The effect of 8 weeks of continuous and high intensity
interval swimming on chemerin levels in liver and visceral fat tissues and insulin resistance in male rats with
metabolic syndrome. Journal of Sport and Exercise Physiology. 2022; 15(1): 33-44. [In Persian].
[https://doi.org/10.52547/ joeppa.15.1.33.
24. Nagle EF, Sanders ME, Franklin BA. Aquatic high intensity interval training for cardiometabolic health:
Benefits and training design. American Journal of Lifestyle Medicine. 2017; 11(1): 64-76. https://doi:10.1177/
1559827615583640.
25. Khalaj A, Ahmadi R. The effect of treadmill exercise on catalepsy from reserpine-induced Parkinson model
in diabetic male rat. KAUMS Journal (FEYZ). 2016;20(5):397-404. [In Persian]
26. Hubrecht RC, Kirkwood J. The UFAW handbook on the care and management of laboratory and other research
animals: John Wiley & Sons; 2010.
27. Abbasi M, Kordi M, Daryanoosh F. The effect of eight weeks of high-intensity interval swimming training on
the expression of PGC-1α and IL-6 proteins and memory function in brain hippocampus in rats with nonalcoholic steatohepatitis induced by high fat diet. Journal of Applied Health Studies in Sport Physiology. 2023.
In press. doi: 10.22049/jahssp.2023.28611.1552.
28. Artzi M, Even-Sapir E, Shacham HL, Thaler A, Urterger AO, Bressman S, et al. DaT-SPECT assessment
depicts dopamine depletion among asymptomatic G2019S LRRK2 mutation carriers. PLoS One. 2017; 12:
e0175424. https://doi.org/10.1371/journal.pone.0175424.
29. Kluss JH, Mamais A, Cookson MR. LRRK2 links genetic and sporadic Parkinson's disease. Biochemical
Society Transaction. 2019: 47(2): 651-661. https://doi.org/10.1042/BST20180462.
30.Rocha EM, Keeney MR, Di Maio R, De Miranda BR, Greenamyre GT. LRRK2 and idiopathic Parkinson’s
disease. Trends in Neurosciences. 2022; 45(3): 224-236. https://doi.org/10.1016/j.tins.2021.12.002
31.Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, et al. (G2019S) LRRK2 activates MKK4-JNK
pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD. Cell Death
and Differentiation. 2012;19(10):1623–1633. http://dx.doi.org/10.1038/cdd.2012.42.
32.Ruffmann C, Giaccone G, Canesi M, Bramerio M, Goldwurm S, Gambacorta M, et al. Atypical tauopathy in
a patient with LRRK2-G2019S mutation and tremor-dominant Parkinsonism. Neuropathology and Applied
Neurobiology. 2012;38(4):382–386. http://dx.doi.org/10.1111/j.1365-2990.2011. 01216.x.
33. Li S, Bi G, Han S, Huang R. MicroRNAs play a role in Parkinson’s disease by regulating microglia function:
From pathogenetic involvement to therapeutic potential. Frontiers in Molecular Neuroscience.
2022;14:744942. https://doi.org/10.3389/fnmol.2021.744942.
34. Fletcher AM, Heaford AC, Trask DK. Detection of metastatic head and neck squamous cell carcinoma using
the relative expression of tissue-specific mir-205. Translational Oncology. 2008; 1:202–208. doi:
10.1593/tlo.08163.
35. Wu H, Mo YY. Targeting miR-205 in breast cancer. Expert Opinion on Therapeutic Targets. 2009;13:1439–
1448. doi: 10.1517/14728220903338777.
36. Patil KS, Basak I, Pal R, Ho HP, Alves G, Chang EJ, et al. A proteomics approach to investigate miR-153-3p
and miR-205-5p targets in neuroblastoma cells. PLoS One. 2015;10(12):e0143969. doi: 10.1371/journal.
pone.0143969.
37. Tiwari PC, Pal R. The potential role of neuroinflammation and transcription factors in Parkinson disease.
Dialogues in Clinical Neuroscience. 2017;19(1):71–80. doi: 10.31887/DCNS.2017.19.1/rpal.
38. Malczynska-Sims P, Chalimoniuk M, Wronski Z, Marusiak J, Sulek A. High-intensity interval training
modulates inflammatory response in Parkinson's disease. Aging Clinical and Experimental Research.
2022;34(9):2165-2176. doi: 10.1007/s40520-022-02153-5.