ورزش و علوم زیست حرکتی

ورزش و علوم زیست حرکتی

تاثیر هشت هفته تمرین ورزشی شنا بر VEGF-A و FGF-2 بافت هیپوکمپ و شاخص لی در رت‌های نر نژاد ویستار

نویسندگان
1 استاد گروه فیزیولوژی ورزشی دانشکده علوم ورزشی دانشگاه تربیت دبیر شهید رجائی تهران ، ایران
2 دانشگاه تربیت دبیر شهید رجائی تهران
3 استادیار گروه فیزیولوژی ورزشی دانشکده علوم ورزشی دانشگاه تربیت دبیر شهید رجائی تهران ، ایران
چکیده
مقدمه و هدف: افزایش پروتئین­ های مرتبط با خون ­رسانی در بافت هیپوکمپ متعاقب تمرین ورزشی شنا احتمالاّ می­ تواند­ ‌از بروز بیماری­ های مغزی مانند آلزایمر جلوگیری کند. هدف تحقیق حاضر تعیین تأثیر هشت هفته تمرین ورزشی شنا بر سطوح VEGF-A و FGF-2 بافت هیپوکمپ و شاخص لی در موش های بزرگ آزمایشگاهی نر نژاد ویستار بود.
مواد و روش ­ها: تعداد 16 سر موش بزرگ آزمایشگاهی نر به طور تصادفی در 2 گروه هشت سری (تمرین شنا و کنترل) تقسیم شدند. گروه تمرین ورزشی شنا هشت هفته، هر هفته 5 روز متوالی برای 60 دقیقه در آب با دمای 2±32 درجه سانتی­ گراد تمرین کردند. برای اندازه گیری سطوح VEGF-A و FGF-2 از روش الایزا، برای اندازه‌­گیری شاخص لی از اندازه ­گیری قد و وزن و برای آزمون فرضیه­ ها از آزمون­ های تی مستقل، یومن ویتنی و ویلکاکسون در سطح 0.05>P < span lang="FA"> استفاده شد.
یافته­ ها: نتایج نشان داد که هشت هفته تمرین شنا با افزایش معنادار VEGF-A (P < /span>=0.002) و FGF-2 (P < /span>=0.0001) هیپوکمپ نسبت به گروه کنترل همراه بود. به علاوه هشت هفته تمرین شنا باعث کاهش معنادار شاخص لی و بهبود توده بدنی در موش­ های بزرگ آزمایشگاهی گردید (0.012=P < span lang="FA">).
بحث و نتیجه گیری: نتایج حاصل از این تحقیق نشان داد که هشت هفته تمرین شنا، باعث افزایش عوامل موثر در رگ زایی در بافت هیپوکمپ و بهبود توده بدنی موش ­های بزرگ آزمایشگاهی نر نژاد ویستار می ­شود.
کلیدواژه‌ها

عنوان مقاله English

Effect of eight weeks swimming exercise training on VEGF-A and FGF-2 of hippocampus tissue and Lee's index in male wistar rats

نویسندگان English

Majid Kashef 1
Mojtaba Sadegh Ghomi 2
Mojtaba Salehpour 3
چکیده English

Introduction and purpose: The increase of proteins related to blood supply in the hippocampus tissue following swimming exercise can probably prevent the occurrence of brain diseases such as Alzheimer's. The aim of the present study was to determine the effect of eight weeks swimming exercise training on VEGF-A and FGF-2 levels of hippocampus tissue and Lee's Index in male Wistar Rats.
Materials and methods: 16 male Rats, divided randomly into 2 groups (swimming exercise training and control). Swimming training group exercised for 8 weeks, 5 consecutive days per week for 60 minutes in water with 32±2˚C of temperature. for evaluation of VEGF-A and FGF-2 Levels used from Elisa Method, To measure Lee's index from height and weight measurements and for hypothesizes test used from Independent T Student, Mann - Whitney U and Wilcoxon tests in level of p≤0.05.
Results: Results show that eight weeks swimming training cause significant increase in VEGF-A (P=0.002) and FGF-2 (P=0.000) in hippocampus tissue compare to control group. Furthermore Eight weeks Swimming training cause significant decrease in Lee's index and improvement of mass index in Rats (P=0.012).
Discussion and Conclusion: Results of this study show that eight weeks swimming exercise training cause increase on effective angiogenic factors in hippocampus tissue and improvement of mass index in male Wistar Rats

کلیدواژه‌ها English

Swimming Exercise training
Hippocampus
VEGF-A
FGF-2
Lee's index
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دوره 11، شماره 22 - شماره پیاپی 22
پاییز و زمستان
اسفند 1398
صفحه 10-18

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