Introduction: Rapid weight loss in lower weight classes of wrestling tournament is an important issue in the field. Purpose: The aim of this study was to investigate the effects of two types of programs of rapid weight loss on heart muscle cell damage and the related index levels.
Methodology:Sixteen young wrestlers (age:18±1.31 years, weight:71.68±13.17 kg, height: 171±6.40 cm) in the form of crossover were randomly divided into two groups (the first group with a weight loss of 2% and the second group with a weight loss of 4% of body weight). Blood samples were analyzed in four stages: before, immediately after, 6, and 24 hours after losing weight. Repeated measures ANOVA was employed and Bonferroni post hoc test was used to analyze the data in various stages.
Results: At the end of the study, a significant increase in the amount of CK-MB in the two groups was observed immediately after weight loss (p=.009). However, this association was unstable and 24 hours after the normal weight loss, CK-MB  reached its normal level. Also, a significant increase in serum LDH levels was observed in the two groups' weight loss (p=.008), while no changes in CK levels were observed in the two groups.
Conclusion: It seems that rapid weight loss by 2% to 4% of body weight can cause serious heart damage. In addition, CK-MB and LDH enzymes showed that rapid weight loss was due to increased levels of these enzymes. Obviously, it is necessary to do further research.