Introduction and purpose: Chemerin is a chemokine that is involved in inflammation and resistance insulin development. Thus, recent study evaluated The ffect of 8 weeks intense resistance training on plasma levels of chemerin and insulin in male rats.
Materials and Methods: 24 male Wister rats (mean weight, 161 ± 23 g and age 5 weeks) were randomly divided into three groups: healthy control, insulin resistance control and insulin resistance training. The rats in insulin resistance training group were subjected to a resistance training program (3 days/wk, for 8 wk) consisted of climbing a ladder carrying a load suspended from the tail. Following eight weeks resistance training plasma chemerin, insulin, glucose and lipid profile concentrations were measured.
Results: The findings showed that resistance training was lead to a significant reduction in plasma chemerin (p= 0.01), glucose (p= 0.001), insulin (p= 0.001) and plasma LDL(0.007) and significant increase in plasma HDL cholesterol (p= 0.03) in insulin resistance training group.
Conclusion: It seems that resistance training with high-intensity can be focused as a prevention approach in insulin resistance.
Key words: Chemerin, insulin resistance ,resistance training, Rat.