Journal of Sports and Biomotor Sciences

Journal of Sports and Biomotor Sciences

The effect of sodium bicarbonate and Dimethylglycine (DMG) administration on biochemical blood parameters and anaerobic function in youth elite basketball players

Document Type : Original Article

Authors
1 Professor, Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
2 Assistant Professor, Department of Physical Education, Farhangian University, Tehtan, Iran.
3 MSc, Laboratory Department, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
4 PhD Student., Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
Abstract
Introduction and Purpose: The dominant energy system in basketball is the anaerobic system, and basketball players are trying to use supplements increasing their anaerobic capacity and power. Therefore, the purpose of the study was to compare the effect of sodium bicarbonate and Dimethylglycine on biochemical blood parameters and anaerobic functions in youth elite basketball players.
Materials and Methods: This study was a semi-experimental study with a repeated measures design. Fifteen youth elite basketball players with 15–17 years old and 72.02±2.56 Kg were divided into three groups: placebo, Sodium bicarbonate, and Dimethylglycine groups. During the study period, a 500 mL solution which contained 300 mg sodium bicarbonate was given to the sodium bicarbonate group. In addition, Dimethylglycine group received 400 mg Dimethylglycine, and third group received 500 mL placebo solution. Blood samples were collected before and following the study’s administrations as well as following Wingate test performance (30 seconds).
Results: Results of this study were demonstrated that following the sodium bicarbonate as well as Dimethylglycine supplements, blood lactate was increased but this finding statistically was not significant (P>0.05). However, following sodium bicarbonate administration the amount of extracellular bicarbonate buffers was significantly increased (P<0.05).
Discussion and Conclusion: Taken our findings together, administration of sodium bicarbonate in youth athletes could increase blood-buffering capacity during the high-intensity interval exercises. Moreover, supplementation of sodium bicarbonate may improve anaerobic capacity due to the buffering capacity ameliorations.
Keywords

Bolton S, Null G. Vitamin B15: a review and update. Orthomol. Psych. 1982; 11(4):260-6.
2. Zajac A, Cholewa J, Poprzecki S, Waskiewicz Z, Langfort J. Effects of sodium bicarbonate ingestion on swim
performance in youth athletes. Journal of sports science & medicine. 2009; 8(1):45.
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc3737792/
3. Hollidge-Horvat MG, Parolin ML, Wong D, Jones NL, Heigenhauser GJ. Effect of induced metabolic alkalosis
on human skeletal muscle metabolism during exercise. American Journal of Physiology-Endocrinology and
Metabolism. 2000; 278(2): 316-29. https://doi.org/10.1152/ajpendo.2000.278.2.E316
4. Chycki J, Golas A, Halz M, Maszczyk A, Toborek M, Zajac A. Chronic ingestion of sodium and potassium
bicarbonate, with potassium, magnesium and calcium citrate improves anaerobic performance in elite soccer
players. Nutrients. 2018 ; 10 (11):1610. https://doi.org/10.3390/nu10111610
5. Attarzadeh-Hosseini R, Abbasian S, Azimkhani A, Onvani V, Joghataie M. The effect of dimethylglycine
(DMG) administration on biochemical blood parameters in youth elite basketball players. International
Research Journal of Biological Science. 2013; 2(2):55-9.
6. McNaughton LR. Sodium bicarbonate ingestion and its effects on anaerobic exercise of various durations.
Journal of sports sciences. 1992; 10(5):425-35. https://doi.org/10.1080/02640419208729941
7. Parry-Billings M, MacLaren DP. The effect of sodium bicarbonate and sodium citrate ingestion on anaerobic
power during intermittent exercise. European journal of applied physiology and occupational physiology.
1986; 55:524-9. https://doi.org/10.1007/bf00421648
8. Thomas C, Perrey S, Lambert K, Hugon G, Mornet D, Mercier J. Monocarboxylate transporters, blood lactate
removal after supramaximal exercise, and fatigue indexes in humans. Journal of Applied Physiology. 2005;
98(3):804-9. https://doi.org/10.1152/japplphysiol.01057.2004
9. Grgic J, Grgic I, Del Coso J, Schoenfeld BJ, Pedisic Z. Effects of sodium bicarbonate supplementation on
exercise performance: an umbrella review. Journal of the International Society of Sports Nutrition. 2021;
18(1):71. https://doi.org/10.1186/s12970-021-00469-7
10. Grgic J, Pedisic Z, Saunders B, Artioli GG, Schoenfeld BJ, McKenna MJ, et al. International Society of Sports
Nutrition position stand: sodium bicarbonate and exercise performance. Journal of the International Society
of Sports Nutrition. 2021; 18(1):61. https://doi.org/10.1186/s12970-021-00458-w
11. Gatarek P, Kaluzna-Czaplinska J. Trimethylamine N-oxide (TMAO) in human health. EXCLI journal. 2021;
20:301. https://doi.org/10.17179%2Fexcli2020-3239
12. Hebestreit H, Meyer F, Heigenhauser GJ, Bar-Or O. Plasma metabolites, volume and electrolytes following
30-s high-intensity exercise in boys and men. European journal of applied physiology and occupational
physiology. 1996; 72:563-9. https://doi.org/10.1007/bf00242291
13. Lindh AM, Peyrebrune MC, Ingham SA, Bailey DM. Sodium bicarbonate improves swimming performance.
International journal of sports medicine. 2008; 29(06):519-23. https://doi.org/10.1055/s-2007-989228
14. Goldfinch J, Mc Naughton L, Davies P. Induced metabolic alkalosis and its effects on 400-m racing time.
European journal of applied physiology and occupational physiology. 1988; 57:45-8. https://doi.org/
10.1007/bf00691236
15.Rowland TW, Maresh CM, Charkoudian N, Vanderburgh PM, Castellani JW, Armstrong LE. Plasma
norepinephrine responses to cycle exercise in boys and men. International journal of sports medicine. 1996;
17(01):22-6. https://doi.org/10.1055/s-2007-972803
16. Pilegaard H, Domino K, Noland T, Juel C, Hellsten Y, Halestrap AP, Bangsbo J. Effect of high-intensity
exercise training on lactate/H+ transport capacity in human skeletal muscle. American Journal of PhysiologyEndocrinology and Metabolism. 1999; 276(2):255-61. https://doi.org/10.1152/ajpendo.1999.276.2.E255
17. McNaughton LR. Sodium citrate and anaerobic performance: implications of dosage. European journal of
applied physiology and occupational physiology. 1990; 61:392-7. https://doi.org/10.1007/bf00236058
18. McNaughton LR. Bicarbonate ingestion: effects of dosage on 60 s cycle ergometry. Journal of sports sciences.
1992; 10(5):415-23. https://doi.org/10.1080/02640419208729940
19. Horswill CA, Costill D, Fink W, Flynn M, Kirwan J, Mitchell J, Houmard J. Influence of sodium bicarbonate
on sprint performance. Medicine and Science in Sports and Exercise. 2004; 36:1239-43. https://pubmed.ncbi.
nlm.nih.gov/3237047/
20. Saunders B, Oliveira LF, Dolan E, Durkalec-Michalski K, McNaughton L, Artioli GG, et al. Sodium
bicarbonate supplementation and the female athlete: A brief commentary with small scale systematic review
and meta-analysis. European journal of sport science. 2022; 22(5):745-54. https://doi.org/10.1080/
17461391.2021.1880649
21. Hilton NP, Leach NK, Hilton MM, Sparks SA, McNaughton LR. Enteric-coated sodium bicarbonate
supplementation improves high-intensity cycling performance in trained cyclists. European journal of applied
physiology. 2020; 120(7):1563-73. https://doi.org/10.1007/s00421-020-04387-5
22. Miranda WA, Barreto LB, Miarka B, Salinas AE, Soto DA, Muñoz EA, Brito CJ. Can Sodium Bicarbonate
Supplementation Improve Combat Sports Performance? A Systematic Review and Meta-analysis. Current
Nutrition Reports. 2022; 11(2):273-82. https://doi.org/10.1007/s13668-022-00396-2
108 ورزش و علوم زیست حرکتی، دوره ،16 شماره ،31 بهار و تابستان 1۴03
23. Guimarães RDS, de Morais Junior AC, Schincaglia RM, Saunders B, Pimentel GD, Mota JF. Sodium
Bicarbonate Supplementation Does Not Improve Running Anaerobic Sprint Test Performance in
Semiprofessional Adolescent Soccer Players. International journal of sport nutrition and exercise metabolism.
2020; 30(5):330-7. https://doi.org/10.1123/ijsnem.2020-0031
24. Grgic J, Rodriguez RF, Garofolini A, Saunders B, Bishop DJ, Schoenfeld BJ, et al. Effects of Sodium
Bicarbonate Supplementation on Muscular Strength and Endurance: A Systematic Review and Meta-analysis.
Sports medicine (Auckland, NZ). 2020; 50(7):1361-75. https://doi.org/10.1007/s40279-020-01275-y
25.Bishop D, Edge J, Davis C, Goodman C. Induced metabolic alkalosis affects muscle metabolism and repeatedsprint ability. Medicine & Science in Sports & Exercise. 2004; 36(5):807-13. https://doi.org/10.1249/01.
mss.0000126392.20025.17
26.Cairns SP. Lactic acid and exercise performance: culprit or friend?. Sports medicine. 2006; 36:279-91.
https://doi.org/10.2165/00007256-200636040-00001
27. Van Montfoort MC, Van Dieren L, Hopkins WG, Shearman JP. Effects of ingestion of bicarbonate, citrate,
lactate, and chloride on sprint running. Medicine & Science in Sports & Exercise. 2004; 36(7):1239-43.
https://doi.org/10.1249/01.mss.0000132378.73975.25
28.Rose RJ, Schlierf HA, Knight PK, Plummer C, Davis M, Ray SP. Effects of N, N-dimethylglycine on
cardiorespiratory function and lactate production in thoroughbred horses performing incremental treadmill
exercise. The Veterinary Record. 1989; 125(10):268-71. https://doi.org/10.1136/vr.125.10.268
29.Bai K, Jiang L, Li Q, Zhang J, Zhang L, Wang T. Dietary dimethylglycine sodium salt supplementation
improves growth performance, redox status, and skeletal muscle function of intrauterine growth-restricted
weaned piglets. Journal of Animal Science. 2021; 99(7):skab186. https://doi.org/10.1093/jas/skab186
30. Mc Naughton LR, Cedaro R. The effect of sodium bicarbonate on rowing ergometer performance in elite
rowers. Australian Journal of Science and Medicine in Sport. 1991; 23(3):66-9.
31. Girandola RN, Wiswell RA, Bulbulian R. Effects of pangamic acid (B-15) ingestion on metabolic response to
exercise. Biochemical medicine. 1980; 24(2):218-22. https://doi.org/10.1016/0006-2944(80)90015-0
32. Peart DJ, Kirk RJ, Hillman AR, Madden LA, Siegler JC, Vince RV. The physiological stress response to highintensity sprint exercise following the ingestion of sodium bicarbonate. European journal of applied
physiology. 2013; 113:127-34. https://doi.org/10.1007/s00421-012-2419-4
33.Beedle BB, Mann CL. Acomparison of Two Warm-Ups on Joint Range of Motion. The Journal of Strength &
Conditioning Research. 2007; 21(3):776-9. http://dx.doi.org/10.1519/R-19415.1
34. Poprzęcki S, Zając A, Wower B, Cholewa J. The effects of a warm-up and the recovery interval prior to
exercise on anaerobic power and acid-base balance in man. J Hum Kinet. 2007; 18:15-28.
35. Verbitsky O, Mizrahi J, Levin M, Isakov E. Effect of ingested sodium bicarbonate on muscle force, fatigue,
and recovery. Journal of Applied Physiology. 1997; 83(2):333-7. https://doi.org/10.1152/jappl.1997.83.2.333
36.Costill DL, Verstappen F, Kuipers H, Janssen E. Acid-basebalance during repeated boutsof exercise: influence
of HCO3.Internationaljournalof sports medicine.1984;5(05):228-31.https://doi.org/10.1055/s-2008-1025910
37. Harrison A, Thompson K. Ergogenic aids: sodium bicarbonate. Peak Performance. 2005;219(219):9-10.
38. Faff J. Invited paper Can the work capacity be improved by inducing pre-exercise alkalosis? Biology of Sport.
1993; 10(3):127.
39.Bai K, Jiang L, Li Q, Zhang J, Zhang L, Wang T. Dietary dimethylglycine sodium salt supplementation
improves growth performance, redox status, and skeletal muscle function of intrauterine growth-restricted
weaned piglets. Journal of animal science. 2021; 99(7). https://doi.org/10.1093/jas/skab186
40. Gao J, Costill DL, Horswill CA, Park SH. Sodium bicarbonate ingestion improves performance in interval
swimming. European journal of applied physiology and occupational physiology. 1988; 58:171-4.
https://doi.org/10.1007/bf00636622
41.Carr AJ, Slater GJ, Gore CJ, Dawson B, Burke LM. Effect of sodium bicarbonate on [HCO3−], pH, and
gastrointestinal symptoms. International journal of sport nutrition and exercise metabolism. 2011; 21(3):189-
94. https://doi.org/10.1123/ijsnem.21.3.189
42. Wu CL, Shih MC, Yang CC, Huang MH, Chang CK. Sodium bicarbonate supplementation prevents skilled
tennis performance decline after a simulated match. Journal of the International Society of Sports Nutrition.
2010; 7:1-8. https://doi.org/10.1186/1550-2783-7-33
43. Tonda ME, Hart LL. N, N dimethylglycine and L-carnitine as performance enhancers in athletes. The Annals
of pharmacotherapy. 1992; 26(7-8):935-7. https://pubmed.ncbi.nlm.nih.gov/1380344/
44. de Oliveira K, Fachiolli DF, Watanabe MJ, Tsuzukibashi D, Bittar CM, Costa C, Poiatti ML, Meirelles PD.
Dimethylglycine supplementation in horses performing incremental treadmill exercise. Comparative Exercise
Physiology. 2015; 11(3):167-72. http://dx.doi.org/10.3920/CEP150016
45. Strous RD, Gibel A, Maayan R. Dimethylglycine (DMG).
46.Cupp MJ, Tracy TS. Dietary supplements: toxicology and clinical pharmacology. Springer Science & Business
Media; 2002.
47. Yao H, Hu Y, Wang Q, Zhang Y, Rao K, Shi S. Effects of dietary dimethylglycine supplementation on laying
performance, egg quality, and tissue index of hens during late laying period. Poultry Science. 2022;
101(2):101610. https://doi.org/10.1016/j.psj.2021.101610
Volume 16, Issue 31 - Serial Number 31
September 2024
Pages 97-109

  • Receive Date 13 March 2024
  • Revise Date 17 September 2024
  • Accept Date 28 September 2024