Journal of Sports and Biomotor Sciences

Journal of Sports and Biomotor Sciences

The Effect of Eight Weeks of Aerobic Training on MDA, TAC, GPX, and SOD in Heart Tissue of Wistar Rats

Document Type : Original Article

Authors
1 Assistant Professor, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Tabriz University, Tabriz, Iran.
2 PhD Student of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Tabriz University, Tabriz, Iran.
3 Associate Professor in Comparative Histology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
Abstract
Introduction and Purpose: Cardiovascular disease is one of the main causes of death in the world. The present study aimed to determine the effect of eight weeks of aerobic exercise on the levels of MDA, TAC, GPX, and SOD in the heart tissue of healthy male Wistar rats.
Materials and Methods: To implement this experimental research, 12 male Wistar rats (weight 253±21 g) aged (8 weeks) were randomly divided into 2 groups including: 1) healthy control and 2) aerobic training. The training protocol involved running on an audio-stimulated treadmill at a speed of 5-24 m/min for 10-60 minutes, 5 days a week for 8 weeks. 48 hours after the last training session, all the rats were anesthetized with a ketamine and xylazine solution. Heart tissue samples were taken from the rats. The levels of MDA, TAC, GPX, and SOD in the heart tissue samples were measured. Data were analyzed by independent t-test was used at a significance level of P<0.05.
Results: The results showed that after eight weeks of intervention, SOD and GPX levels increased and TAC and MDA decreased in the training group compared to the control group, but these changes were not significant (P>0.05).
Discussion and Conclusion: According to the obtained results, it is possible to say that regular aerobic training can have positive effects on the efficiency of the body's antioxidant system and neutralize the harmful effects of free radicals. Also, regular aerobic training in rats does not lead to oxidative stress.
Keywords

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Volume 16, Issue 31 - Serial Number 31
September 2024
Pages 44-55

  • Receive Date 02 February 2024
  • Revise Date 20 April 2024
  • Accept Date 06 May 2024