Journal of Sports and Biomotor Sciences

Journal of Sports and Biomotor Sciences

Comparison of the effect of 12 week of endurance training and HIIT on Plasma values of Vaspin in obese male wistar rats

Document Type : Original Article

Authors
Mostafa Soltani 1
Mitra Aghahaji 2
Nematallah Nemati 3
1 Assistant Professor, Department of Sport Sciences, Faculty of Social Sciences, Imam khomeini International University, Qazvin, Iran
2 MSC of Clinical Physiology, Damghan Education, Damghan, Iran
3 Associate Professor of Exercise Physiology, Islamic Azad University, Damghan Branch, Damghan, Iran
10.22034/sbs.2022.372324.0
Abstract
Introduction and purpose: Vaspin is one of the peptide adipocytokines secreted from adipose tissue, which plays a role in the pathogenesis of obesity and related disorders. Vaspin has recently been identified as a new adipocytokine with the effects of increasing insulin sensitivity. There is little information about the effects of exercise on vaspin concentration. The present study has studied the effect of endurance training and HIIT on the plasma concentration of vaspin in obese male wistar rats.
Materials and methods: The current research was of a randomized experimental type with a comparison design of two control and experimental groups. 30 rats (mean and standar deviation of weight 200±20 gr and age 8 weeks) were randomly divided into 3 groups: control group, endurance training, and HIIT training. All 3 groups included 10 rats.  For 12 weeks, experimental groups did exercises based on exercise programs -three days a week, while the control group had no exercise. Following 12 weeks training, plasma vaspin were measured. 36 hours after the last training session and 10 hours of fasting, the blood samples of rats of all groups were taken directlyfrom the heart after cutting the peritoneal region. The Kruskal-Wallis test was used to compare the average of three research groups and the U-ManWhitney test was used to compare the pairwise averages at a significance level of P≤ 0.05.
Results: After 12 weeks of endurance and HIT training, Vaspin levels, in practice Group endurance and HIT compared with the control group significantly decreased (P=0.001). This study showed both types of endurance training and HIIT, significantly improve Vaspin levels.
Discussion and Conclusion: According to the results of the present study, it can be stated that endurance training and HIIT can be considered as a solution to reduce fat tissue and adipocytokines, including vaspin and other pro-inflammatory factors.
Keywords
Adipose tissue
Adipocytokine
Exercise
Rat
Vaspin
Indelicato JA. Association between executive function, physical activity and physical fitness in people with typ2
diabetes, a thesis, Northeastern University. 2018.
2. Martos Moreno GA. Serum visfatin and vaspin levels in prepubertalchildren: effect of obesity and weight loss after
behavior modifications on theirsecretion and relationship with glucosemetabolism. J Obesity, 2011; 35: 55-62.
3. Ouchi N, Kihara S, Funahashi T, Nakamura T, Nishida M, Kumada M. Reciprocal association of C-Reactive protein with
adiponectin in blood stream and adipose tissue, J Rehabil Med. 2013; 107(5): 671-684.
4. Antoniades C, Antonopoulos AS, Tousoulis D, Stefanadis C. Adiponectin: from obesity to cardiovascular disease,
Obesity Rev (2009); 10: 269-275.
5. Reaven G, Abbasi F, McLaughlin T. Obesity, insulinresistance, and cardiovascular disease. Recent Prog HormRes. 2004;
59: 207–223.
6. Gantiraga E, Katartzi E, Komsis G, Papadopoulos C. Strength and vertical jumping performance characteristics in schoolaged boys and girls. Biol. Sport. 2006; 23(4): 356- 367.
7. Chang HM, Park HS, Park CY, Song YS, & Jang Y J. Association between serum vaspin concentrations and visceral
adipose tissue in Korean subjects. Metabolism. 2010; 59(9): 1276-1281.
8. Jin K, Tae Kyung H, Hyun S. Combined effects of body mass index and cardio/respiratory fitness on serum vaspin
concentrations in Korean young men. Eur. J. Appl. Physiol. 2020; 108(2): 347-353.
9. Wada J. Vaspin: a novel serpin with insulin-sensitizing effects . Expert Opin. Investig. Drugs. 2008; 17: 327–333.
10. Kloting N, Berndt J, Kralisch S, Kovacs P, Fasshauer M, Stumvoll M. Vaspin gene expression in human adipose tissue:
association with obesity and type 2 diabetes. Biochem. Biophys. Res. Commun. 2006; 339: 430–436.
11. Saremi A, Shavandi N, Parastesh M, Daneshmand H. Twelve-week aerobic training decreases chemerin level and
improves cardiometabolic risk factors in overweight and obese men. Asian J Sports Med. 2010; 1(3): 151-158. [In Persian].
12. Safarzade A, Talebi-Garakani E. Effects of progressive resistance training on serum levels of vaspin and some
inflammatory markers in male rats. Koomes, 2012; 14 (1): 97-103. [In Persian].
13. Hosseini SA, Zar A, Kheirdeh M, Arayesh Oliaei A. Effect of endurance training on vaspine and glycemic indexes in
diabetic rats. Qom Univ Med Sci J. 2017; 10(11):17-24. [In Persian]
14. Asgarihazaveh D , RiyahiMalayeri SH, Babaei S. investigate the effect of eight weeks high intensity interval training and moderate intensity interval training and Aloe vera intake on serum vaspin and insulin resistance in diabetic male rats.
AMUJ. 2018; 20(128): 67-75. [In Persian].
15. Hejazi K, AttarzadehHosseini SR, Fathie M, MosaferiZiaaldini M, Zaeemi M. The response of serum levels of irisin to
eight weeks of aerobic training with moderate intensity in male obese Wistar rats. Scientific Bi-Quarterly of Shahed
University 25th Year, No.133 February- March 2018. 49-57. [In Persian].
16. Sarmi A, Parastesh M, Bayat M, Jawaharlalab Z. The effect of 10 weeks of endurance, resistance and combined training
on the serum level of vaspin and insulin resistance index in type 2 diabetic rats, National Congress of Sports Medicine
Approach in Injury and new sports science seminar, 2018; Sari, https://civilica.com/doc/962092.[In Persian].
17. Tokmakidis SP, Zois CE, Volaklis KA, Kotsa K, Touvra AM. The effects of a combined strength and aerobic exercise
program on glucose control and insulin action in women with type 2 diabetes. European journal of applied physiology.
2021; 92: 437- 42.
18. Kadoglou PE, Vrabas IS, Kapelouzou A, Angelopoulou N. The association of physical activity with novel adipokines
and patients with type2 diabetes. Eur. J. Intern. Med. 2012; 23(5): 137-142.
19. Kyung Han, T, Hyun. K. Effects of acute execise on serum vaspin and insulin resistance in normal and pre- diabetes
middle-aged women. J Exerc Nutrition Biochem. 2019; 16(1): 11-18.
20. Youn BS, Klöting N, Kratzsch J, Lee N, Park JW, Song ES. Serum vaspin concentrations in human obesity and type 2
diabetes. Diabetes. 2018; 57(2):372–377.
21. Hida K, Wada J, Zhang H, Hiragushi K, Tsuchiyama. Y, Shikata. K. Identification of genes specifically expressed in the
accumulated visceral adipose tissue of OLETF rats. J Lipid Res; 2005; 41(3): 15-22.
22. Abdel-lateif, D. M., & El-Shaer, S. S. Association between changes in serum vaspin concentrations and changes of
anthropometric and metabolic variables in obese subjects after weight reduction. Am. J. Sci. 2020; 8(4): 35-51.
23. Hejazi M, Nezam Dost Z, Sagebjo M. The effect of 12 weeks of aerobic training on the serum level of leptin, vaspin and
some oxidative stress indicators in obese middle-aged women, Iran. J Endocrinol Metab. 2013; 16 (2): 111-118. [In Persian].
24. Dabaghzadeh, R, Kazemi A, Rahmati M, Raisi S, Molai Sarbijan S. The effect of a period of high-intensity interval
training on serum visfatin and vaspin, insulin resistance, lipid profile and body composition of overweight men. Bimonth
J Med Daneshvar. 2013; 22 (114): 55- 68. [In Persian].
25. Sharafati Moghadam M, Daryanosh F, Mohammadi M, Koshki Jahormi M, Alizadeh Pahlwani H. Investigation of the
effect of eight weeks of intense speed training on the plasma levels of Vaspin and Camerin in female Spraguedaoli rats,
Bimonth J Med Daneshvar. 2012; 107: 241-250. [In Persian].
26. Kasapis C, Thompson PD. The effects of physical activity on serum Creactive protein and inflammatory markers: a
systematic review. J Am Coll Cardiol; (2005). 45(10): 1563-9.

  • Receive Date 12 September 2022
  • Accept Date 12 November 2022