Journal of Sports and Biomotor Sciences

Journal of Sports and Biomotor Sciences

Effect of eight week progressive resistance training on walking ability, fatigue and quality of life in women with Multiple Sclerosis

Document Type : Original Article

Authors
1 Ph.D in Exercise Physiology, Department of Sport Sciences, Razi University, Kermanshah, Iran
2 Assistant Professor, Department of Sports Physiology, Bandar Abbas Branch, Islamic Azad University, Bandar Abbas, Iran
3 Msc in Exercise Physiology, Department of Sport Sciences, Faculty of Literature & Human Sciences, Lorestan University, Khorramabad, Iran
Abstract
Introduction and purpose: Exercise training is an effective strategy to multiple sclerosis treatment. This study investigated the effect of progressive resistance training on walking ability, fatigue and quality of life in women with MS.
Materials and Methods: For this purpose, sixteen women with MS participated in this study. Subjects randomly were divided to control (32.37±8.15 years old) and experimental groups (29.71±5.37 years old). The experimental group participated in a graduate resistance training program for 8 weeks, 3 days/week, 40-70% of 1-Repetition Maximum (1-RM). Before and after exercise training, walking speed, walking endurance, fatigue and quality of life were measured in control and experimental groups. Repeated measure ANOVA was used to statistical analyses. Significance level was set to < 0.05.
Results: Walking ability (endurance and speed walking) after 8 weeks resistance training significantly increased in experimental group (P=0.0001); while, walking ability decreased significantly in the control group (P=0.04). In the other hand, fatigue in experimental group significantly decreased (P=0.001), while in the control group insignificantly increased (P=0.73). Also, resistance training improved the mental health and quality of life of women with MS, while it decreased in control group (P= 0.04). On the other hand, there is no significant difference between the two groups in the quality of life and fatigue before and after training, but the walking ability (speed and endurance) after training in the experimental group was significantly higher than the control group.
Discussion and Conclusion: It seems that 8 weeks of progressive moderate-intensity resistance training can lead to increased walking ability and decreased fatigue, and ultimately lead to improved mental health and quality of life in women with MS.
Keywords

1. Ahmadi A, Arastoo AA, Nikbakht M, Zahednejad S, Rajabpour M. Comparison of the effect of 8 weeks aerobic and
yoga training on ambulatory function, fatigue and mood status in MS patients. Iran. Red Crescent Med. J. 2013;
15(6):449.
2. Hughes MD. Multiple sclerosis and pregnancy. Neurol Clin. 2004;22(4):757-69.
3. Etemadifar M, Janghorbani M, Shaygannejad V, Ashtari F. Prevalence of multiple sclerosis in Isfahan, Iran.
Neuroepidemiology. 2006;27(1):39-44.
4. Etemadifar M, Maghzi A-H. Sharp increase in the incidence and prevalence of multiple sclerosis in Isfahan, Iran. Mult
Scler Int. 2011;17(8):1022-7.
5. Howarth AL. Will aromatherapy be a useful treatment strategy for people with multiple sclerosis who experience pain?
Complement Therap Nurs Midwife. 2002;8(3):138-41.
6. Edwards T, Pilutti LA. The effect of exercise training in adults with multiple sclerosis with severe mobility disability: a
systematic review and future research directions. Mult Scler Relat Disord. 2017;16:31-9.
7. Fernández O, Baumstarck-Barrau K, Simeoni M-C, Auquier P, Group MS. Patient characteristics and determinants of
quality of life in an international population with multiple sclerosis: assessment using the MusiQoL and SF-36
questionnaires. Mult Scler. 2011;17(10):1238-49.
8. Andreasen A, Stenager E, Dalgas U. The effect of exercise therapy on fatigue in multiple sclerosis. Mult Scler.
2011;17(9):1041-54.
9. Surakka J, Romberg A, Ruutiainen J, Aunola S, Virtanen A, Karppi S-L, et al. Effects of aerobic and strength exercise on
motor fatigue in men and women with multiple sclerosis: a randomized controlled trial. Clinic Rehab. 2004;18(7):737-46.
10. Fragoso YD, Silva ÉOd, Finkelsztejn A. Correlation between fatigue and self-esteem in patients with multiple sclerosis.
Arq Neuropsiquiatr. 2009;67(3B):818-21.
11. Eftekhari E, Nikbakht H, RABIEI K, Etemadifar M. Effect of endurance training on aerobic power and quality of life in
female patients with multiple sclerosis. Iran epidemiol. 2008; 14(1): 95-104. [In Persian]
12. Motl RW, McAuley E, Snook EM, Gliottoni RC. Physical activity and quality of life in multiple sclerosis: intermediary
roles of disability, fatigue, mood, pain, self-efficacy and social support. Psychol Health Med. 2009;14(1):111-24.
13. Petajan JH, Gappmaier E, White AT, Spencer MK, Mino L, Hicks RW. Impact of aerobic training on fitness and quality
of life in multiple sclerosis. Ann Neurol. 1996;39(4):432-41.
14. Latimer-Cheung AE, Pilutti LA, Hicks AL, Ginis KAM, Fenuta AM, MacKibbon KA, et al. Effects of exercise training
on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: a systematic review to
inform guideline development. Arch Phys Med Rehabil. 2013;94(9):1800-28. e3.
15. Dalgas U, Stenager E, Jakobsen J, Petersen T, Overgaard K, Ingemann-Hansen T. Muscle fiber size increases following
resistance training in multiple sclerosis. Mult Scler. 2010;16(11):1367-76.
16. Rampello A, Franceschini M, Piepoli M, Antenucci R, Lenti G, Olivieri D, et al. Effect of aerobic training on walking
capacity and maximal exercise tolerance in patients with multiple sclerosis: a randomized crossover controlled study.
Phys Ther. 2007;87(5):545-55.
17. Wolinsky JS, Group PS. The diagnosis of primary progressive multiple sclerosis. J Neurol Sci. 2003;206(2):145-52.
18. Broekmans T, Roelants M, Feys P, Alders G, Gijbels D, Hanssen I, et al. Effects of long-term resistance training and
simultaneous electro-stimulation on muscle strength and functional mobility in multiple sclerosis. Mult Scler.
2011;17(4):468-77.
19. Gutiérrez-Cruz C, Rojas-Ruiz FJ, la Cruz-Márquez D, Carlos J, Gutiérrez-Dávila M. Effect of a combined program of
strength and dual cognitive-motor tasks in multiple sclerosis subjects. Int J Environ Res Public Health.
2020;17(17):6397.
20. Pierre Z. High-intensity interval training combined with resistance training improves physiological capacities, strength
and quality of life in multiple sclerosis patients: a pilot study. Eur J Phys Rehabil Med. 2018; 54(1):58-67.
21. Kjølhede T, Vissing K, Dalgas U. Multiple sclerosis and progressive resistance training: a systematic review. Mult Scler.
2012;18(9):1215-28.
22. Morrison EH, Cooper DM, White LJ, Larson J, Leu S-Y, Zaldivar F, et al. Ratings of perceived exertion during aerobic
exercise in multiple sclerosis. Arch Phys Med Rehabil. 2008;89(8):1570-4.
23. Sandroff BM, Bollaert RE, Pilutti LA, Peterson ML, Baynard T, Fernhall B, et al. Multimodal exercise training in
multiple sclerosis: a randomized controlled trial in persons with substantial mobility disability. Contemp Clin Trials.
2017;61:39-47.
24. Motl RW, Goldman MD, Benedict RH. Walking impairment in patients with multiple sclerosis: exercise training as a
treatment option. Neuropsychiatr. Dis Treat. 2010;6:767.
25. Kargarfard M, Etemadifar M, Asfarjani F, Mehrabi M, Kordavani L. Changes in quality of life and fatigue in women
with multiple sclerosis after 8 weeks of aquatic exercise training. J Ment Health. 2010;12(3):562-73.
26. White LJ, Dressendorfer RH. Exercise and multiple sclerosis. Sports Med. 2004;34(15):1077-100.
27. White L, McCoy S, Castellano V, Gutierrez G, Stevens J, Walter G, et al. Resistance training improves strength and
functional capacity in persons with multiple sclerosis. Mult Scler. 2004;10(6):668-74.
28. Yousefvand Z, Parnow A, Ahsan B, Fayazi B. Effect of 8-week Resistance Training on Muscle Strength and Functional
Capacity in Women with Multiple Sclerosis (MS). Sabzevar Sport Biomotor Sci. 2013;3(2):82-71. [In Persian]
29. Stroud NM, Minahan CL. The impact of regular physical activity on fatigue, depression and quality of life in persons
with multiple sclerosis. Health Qual Life Outcomes. 2009;7(1):68.
30. Dodd K, Taylor N, Shields N, Prasad D, McDonald E, Gillon A. Progressive resistance training did not improve walking
but can improve muscle performance, quality of life and fatigue in adults with multiple sclerosis: a randomized controlled
trial. Mult Scler. 2011;17(11):1362-74.
31. Gutierrez GM, Chow JW, Tillman MD, McCoy SC, Castellano V, White LJ. Resistance training improves gait
kinematics in persons with multiple sclerosis. Arch Phys Med Rehabil. 2005;86(9):1824-9.
32. Hameau S, Zory R, Latrille C, Roche N, Bensmail D. Relationship between neuromuscular and perceived fatigue and
locomotor performance in patients with multiple sclerosis. Eur J Phys Rehabil Med. 2017;53(6):833-40.
33. Abadi Marand L, Noorizadeh Dehkordi S, Roohi-Azizi M, Dadgoo M. Effect of dynamic neuromuscular stabilization on
balance and trunk function in people with multiple sclerosis:protocol for a randomized control trial. Trials.2022;23(1):1-9.
34. Filli L, Sutter T, Easthope CS, Killeen T, Meyer C, Reuter K, et al. Profiling walking dysfunction in multiple sclerosis:
characterisation, classification and progression over time. Sci Rep. 2018;8(1):1-13.
35. Fritz NE, Marasigan RER, Calabresi PA, Newsome SD, Zackowski KM. The impact of dynamic balance measures on
walking performance in multiple sclerosis. Neurorehabil Neural Repair. 2015;29(1):62-9.
36. Vanage SM, Gilbertson KK, Mathiowetz V. Effects of an energy conservation course on fatigue impact for persons with
progressive multiple sclerosis. Am J Occup Ther. 2003;57(3):315-23.
37. Dalgas U, Stenager E, Jakobsen J, Petersen T, Hansen HJ, Knudsen C, et al. Resistance training improves muscle
strength and functional capacity in multiple sclerosis. Neuro. 2009;73(18):1478-84.
38. Motl R, Goldman M. Physical inactivity, neurological disability, and cardiorespiratory fitness in multiple sclerosis. Acta
Neurol Scand. 2011;123(2):98-104.
39. Ahmadi A, Nikbakh M, Arastoo A, Habibi A-H. The effects of a yoga intervention on balance, speed and endurance of
walking, fatigue and quality of life in people with multiple sclerosis. J Hum Kinet. 2010;23:71-8.
40. Fayazi B, Parnow A, Ahsan B, Yousefvand Z. The Effect Aerobic Training on Functional Capacity and Percent Body Fat
in Women with Moderate Multiple Sclerosis (MS). Journal of Arak University of medical sciences. 2013; 16(70):97-87.
[In Persian]
41. Hayes HA, Gappmaier E, LaStayo PC. Effects of high-intensity resistance training on strength, mobility, balance, and
fatigue in individuals with multiple sclerosis: a randomized controlled trial. J Neurol Phys Ther. 2011;35(1):2-10.
42. Motl RW, Gosney J. Effect of exercise training on quality of life in multiple sclerosis: a meta-analysis. Mult Scler.
2008;14(1):129-35.
43. Huisinga JM, Filipi M, Stergiou N. Elliptical exercise improves fatigue ratings and quality of life in patients with
multiple sclerosis. J Rehabil Res Dev. 2011; 48 (7):881-90.
44. Hart S, Fonareva I, Merluzzi N, Mohr DC. Treatment for depression and its relationship to improvement in quality of life
and psychological well-being in multiple sclerosis patients. Qual Life Res. 2005; 14(3):695-703.
Volume 14, Issue 27 - Serial Number 27
September 2022
Pages 72-81

  • Receive Date 09 August 2022
  • Accept Date 08 October 2022