Journal of Sports and Biomotor Sciences

Journal of Sports and Biomotor Sciences

The impact of half marathon running on changes of cardiac biomarkers ST2, NT-proBNP and Troponin-T in middle-age endurance runners

Author
Roohollah Mohammadi Mirzaei
10.22034/sbs.2021.161241
Abstract
Introduction and purpose: endurance running associated with structural, functional and inflammatory cardiovascular changes. The aim of the present study was to investigate the effects of half marathon on cardiovascular damage Biomarkers.(NT-proBNP),ST2 and troponin-T(hs-TnT)were assayed.
Materials and Methods: in this study, 80 non-elite trained male marathon runners (age 40±6 years, weight 76±8 kg, height 177±8 cm and BMI24±2 kg/m2) participated voluntarily. Blood samples at baseline (24-48 hours before the race), after the race (1-2hours after the match) and 48 hours after the race. The race was held on the track of Chitgar Park cycling track for a distance of 21km.  The average training of volunteers   was 7years and the average weekly training hour was 6 hours and the average competition best time was 104±6min. To analyze the data, repeated measures analysis of variance and correlation and regression tests were used. With confidence interval of P<0.05.
Results: The results show that immediately after the race the rate of is associated with an increase of 1/3 in NT-pro BNP, 1/6 in ST2 and 16-fold in hs-TnT (P≤0.05). In the results of 48 hours after the competition, an inverse and significant relationship was observed between the hours of weekly training and the increase in ST2 (P<0.05). Also, a direct and significant relationship was shown between the end time of the race and the rate of increase in hs-TnT (P<0.001) A direct and significant relationship was shown between the end time of the race and the amount of ST2 changes (P<0.05).
Discussion and Conclusion: it seems that Participation in endurance events through various pathways appears to cause markers of cardiovascular damage. Therefore, increasing the concentration of these markers may increase the risk of heart attack and sports sudden cardiac death in athletic without symptoms of cardiovascular disease.
Keywords
Cardio damage
half Marathon
ST2
Troponin-T
NT-proBNP
1. Lee D-c, Pate RR, Lavie CJ, Sui X, Church TS, Blair SN. Leisure-time running reduces all-cause and cardiovascular mortality risk. Journal of the American College of Cardiology. 2014;64(5):472-81. doi: 10.1111/sms.12463 2. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, Vasileva EY. Task Force for the Universal Definition of Myocardial Infarction. Third universal definition of myocardial infarction. Nature Reviews Cardiology. 2012;9(11):620-33. doi: 10.1038/nrcardio.2012.122 3. Fu F, Nie J, Tong T. Serum cardiac troponin T in adolescent runners: effects of exercise intensity and duration. International journal of sports medicine. 2009;30(03):168-72. doi: 10.1055/s-0028-1104586 4. Eijsvogels TM, Fernandez AB, Thompson PD. Are there deleterious cardiac effects of acute and chronic endurance exercise? Physiological reviews. 2016;96(1):99-125. 10.1152/physrev.00029.2014 5. Legaz-Arrese A, López-Laval I, George K, Jose Puente-Lanzarote J, Castellar-Otín C, Reverter-Masià J, et al. Individual variability of high-sensitivity cardiac troponin levels after aerobic exercise is not mediated by exercise mode. Biomarkers. 2015;20(4):219-24. doi: 10.3109/1354750x.2015.1068851 6. Tian Y, Nie J, George KP, Huang C. Reproducibility of cardiac biomarkers response to prolonged treadmill exercise. Biomarkers. 2014;19(2):114-20. doi: 10.3109/1354750X.2014.880855 7. Kong Z, Nie J, Lin H, George K, Zhao G, Zhang H, et al. Sex differences in release of cardiac troponin T after endurance exercise. Biomarkers. 2017;22(3-4):345-50. doi: 10.1080/1354750X.2016.1265007 8. Li F, Hu Y, Nie J, Fu F. Effects of acute, intermittent exercise in hypoxic environments on the release of cardiac troponin. Scandinavian journal of medicine & science in sports. 2016;26(4):397-403. doi: 10.1111/sms.12463 9. Richardson AJ, Leckie T, Watkins E, Fitzpatrick D, Galloway R, Grimaldi R, et al. Post marathon cardiac troponin T is associated with relative exercise intensity. Journal of science and medicine in sport. 2018;21(9):880-4. doi: 10.1016/j.jsams.2018. 10. Gresslien T, Agewall S. Troponin and exercise. International journal of cardiology. 2016;221:609-21. doi: 10.1016/j.ijcard.2016.06.243 11. Clerico A, Fontana M, Zyw L, Passino C, Emdin M. Comparison of the diagnostic accuracy of brain natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP immunoassays in chronic and acute heart failure: a systematic review. Clinical chemistry. 2007;53(5):813-22. doi.org/10.1373/clinchem.2006.075713 12. Nie J, Tong T, George K, Fu F, Lin H, Shi Q. Resting and post‐exercise serum biomarkers of cardiac and skeletal muscle damage in adolescent runners. Scandinavian journal of medicine & science in sports. 2011;21(5):625-9. doi/abs/10.1111/j.1600-0838.2010.01096.x 13. Shave R, Baggish A, George K, Wood M, Scharhag J, Whyte G, et al. Exercise-induced cardiac troponin elevation: evidence, mechanisms, and implications. Journal of the American College of Cardiology. 2010;56(3):169-76. doi: 10.1016/j.jsams.2010. 14. Bayes-Genis A, Januzzi JL, Gaggin HK, De Antonio M, Motiwala SR, Zamora E, et al. ST2 pathogenetic profile in ambulatory heart failure patients. Journal of Cardiac Failure. 2015;21(4):355-61. doi.org/10.1016/j.cardfail.2014.10.014 15. Ford I, Shah AS, Zhang R, McAllister DA, Strachan FE, Caslake M, et al. High-sensitivity cardiac troponin, statin therapy, and risk of coronary heart disease. Journal of the American College of Cardiology. 2016;68(25):2719-28. doi.org/10.1016/j.atherosclerosis.2015.04.062 16. Neilan TG, Januzzi JL, Lee-Lewandrowski E, Ton-Nu T-T, Yoerger DM, Jassal DS, et al. Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. Circulation. 2006;114(22):2325-33. doi.org/10.1161/CIRCULATIONAHA.106.647461 17. Huang W-S, Lee M-S, Perng H-W, Yang S-P, Kuo S-W, Chang H-D. Circulating brain natriuretic peptide values in healthy men before and after exercise. Metabolism-Clinical and Experimental. 2002;51(11):1423-6. doi.org/10.1053/meta.2002.35194 18. Scharhag J, Urhausen A, Herrmann M, Schneider G, Kramann B, Herrmann W, et al. No difference in N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations between endurance athletes with athlete’s heart and healthy untrained controls. Heart. 2004;90(9):1055-6. doi.org/10.1136/hrt.2003.020420 19. Melanson SE, Green SM, Wood MJ, Neilan TG, Lewandrowski EL. Elevation of myeloperoxidase in conjunction with cardiac-specific markers after marathon running. American journal of clinical pathology. 2006;126(6):888-93. doi.org/10.1309/1D62H6KRFTVQRJ0A 20. Aengevaeren VL, van Kimmenade RR, Ordóñez‐Llanos J, García‐Osuna Á, Kaier TE, Marber M, et al. Cardiac Biomarker Kinetics and Their Association With Magnetic Resonance Measures of Cardiomyocyte Integrity Following a Marathon Run: Implications for Postexercise Biomarker Testing. Journal of the American Heart Association. 2021;10(13):e020039. doi.org/10.1161/JAHA.120.020039 21. La Gerche A, Connelly KA, Mooney DJ, MacIsaac AI, Prior DL. Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise. Heart. 2008;94(7):860-6. doi.org/10.1136/hrt.2006.101063 22. Knebel F, Schimke I, Schroeckh S, Peters H, Eddicks S, Schattke S, et al. Myocardial function in older male amateur marathon runners: assessment by tissue Doppler echocardiography, speckle tracking, and cardiac biomarkers. Journal of the American Society of Echocardiography. 2009;22(7):803-9. doi.org/10.1016/j.echo.2009.04.009 23. Mousavi N, Czarnecki A, Kumar K, Fallah-Rad N, Lytwyn M, Han S-Y, et al. Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. The American journal of cardiology. 2009;103(10):1467-72. doi.org/10.1016/j.amjcard.2009.01.294 24. Serrano‐Ostáriz E, Terreros‐Blanco JL, Legaz‐Arrese A, George K, Shave R, Bocos‐Terraz P, et al. The impact of exercise duration and intensity on the release of cardiac biomarkers. Scandinavian journal of medicine & science in sports. 2011;21(2):244-9. doi.org/10.1111/j.1600-0838.2009.01042.x 25. Lippi G, Schena F, Salvagno GL, Montagnana M, Gelati M, Tarperi C, et al. Influence of a half-marathon run on NT-proBNP and troponin T. Clinical Laboratory Journal For Clinical Laboratories And Laboratories Related. 2008;54(7):251. doi.org/10.1016/j.amjcard.2009.01.294 26. Kociol RD, Pang PS, Gheorghiade M, Fonarow GC, O'Connor CM, Felker GM. Troponin elevation in heart failure: prevalence, mechanisms, and clinical implications. Journal of the American College of Cardiology. 2010;56(14):1071-8. doi/abs/10.1016/j.jacc.2010.06.016
Journal of Sports and Biomotor Sciences
Volume 13, Issue 25 - Serial Number 25
September 2021
Pages 49-56

  • Receive Date 23 November 2022
  • Revise Date 27 February 2023