Background: Diabetes mellitus is a metabolic abnormality associated with neuropathy, kidney complications, coronary artery disease and peripheral arteries, arteriosclerosis, hypertension and systemic inflammation. The use of high intensity interval training and progressive resistance training  to treat metabolic disorders such as diabetes which blood  glucose and insulin tolerance
has an important role in reducing its side effects, is common among people. the aim of this study was to investigate the effect of high intensity interval training and progressive  resistance training on differentiation of myeloid 88 gene expression and serum levels of TNF-α.
Materials and Methods : 72 Rats (6 weeks old) weighing 150 g were randomly divided into six groups of 12 consist of: Control group(C), Diabetes group (D), Diabetes –High Intensity Interval Training (DIT) and High intensity Interval Training (HIIT), Diabetes –progressive resistance training(DRT), resistance training(RT)  groups. Six weeks of High Intensity Interval and progressive resistance training were done 3 days a week. Gene expression was performed using the Real-Time PCR technique and the calculation of the changes using the 2-ΔΔCT method. Serum levels of TNF-α were measured by ELISA method. The data were analyzed by Fisher and M-ANOVA tests at a significant level of p≤0/01.
Results and Conclusion: The findings of the present study showed a significant increase in both factors of myeloid 88 gene expression and serum levels of TNF-α. As a result, High Intensity Interval training and progressive resistance training reduced the negative effects of diabetic cardiomyopathy by activating the pathway and different molecular cell mechanisms dramatically