Effect of Intensive Resistance Exercise Training on Protein Expression of IL-6, IL-1Î² and TNF-Î± myokines in fast twitch skeletal muscle of diabetic rats

Molanouri Shamsi, Mahdieh; Mahdavi, Mehdi; Gharakhanlou, Reza; Hassan, Mohammad Zohair

doi:10.22034/sbs.2023.371653.0

Effect of Intensive Resistance Exercise Training on Protein Expression of IL-6, IL-1Î² and TNF-Î± myokines in fast twitch skeletal muscle of diabetic rats

Document Type : Original Article

Authors

Mahdieh Molanouri Shamsi

Mehdi Mahdavi

Reza Gharakhanlou

Mohammad Zohair Hassan

10.22034/sbs.2023.371653.0

Abstract

Introduction: It suggested that cytokines or other peptides that are produced, expressed and released by muscle fibres (usually during contraction) and exert endocrine effects should be classified as myokines. Many proteins produced by skeletal muscle are dependent upon contraction. Therefore, it is likely that myokines may contribute in the mediation of the health benefits of exercise. Our aim was to investigate effect of intensive resistance exercise training on protein expression of IL-6, IL-1Î² and TNF-Î± myokines in skeletal muscle in rats with diabetes. Materials and methods: Rats were divided into control, training, streptozotocin induced diabetic and diabetic training groups. Training groups performed for Resistance training consisted of climbing a 1 m ladder with increasing weight added to the tail. Protein expression of myokines in FHL skeletal muscle measured by ELIZA method. Results: The results of this study indicate that training and diabetes interaction was significant for IL-6 in FHL muscle (P

Keywords

Diabetes

Myokine

Resistance Training

Skeletal Muscle