نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشجو
2 گروه تربیت بدنی، دانشکده علوم انسانی، واحد بجنورد، دانشگاه آزاد اسلامی، بجنورد، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Introduction and Purpose: Obesity by inducing insulin malfunction increases fasting glucose in diabetic patients. Thus, the aim of this study was to investigate the impact of eight weeks of aerobic training on sirtuin-1 and insulin resistance index (HOMA-IR) in overweight and obese men with type 2 diabetes.
Materials and Methods: Twenty-two obese men with type 2 diabetes (Age: 35.7± 4.9 years, body mass index (BMI): 30.45± 2.35 kg/m2) volunteered to participate in the study and divided into two groups of Training and control based on their fasting blood glucose levels. Subjects in training group participated in eight weeks of aerobic training at intensity of 70 percent of maximum heart rate, three sessions per week and 45-50 minutes per session. Blood samples were collected before training and 48 hours after the last training session to measure the investigating blood factors (Sirtuin-1, insulin, glucose and HOMA-IR). Data were analyzed by ANOVA repeated measure (2×2) for between groups and paired t-test for within each group.
Results: The results showed that eight weeks of aerobic training resulted in significant increase in the serum levels of sirtuin-1, and significant decrease in insulin, fasting blood glucose, and HOMA-IR, body weight and BMI as well in post-test compared to the pre-test (P<0.05). Moreover, compared to the control group, serum levels of sirtuin-1 increased and insulin, glucose and HOMA-IR, body weight, and BMI decreased significantly (P<0.05). Additionally, there were significant correlations between changes in serum levels of sirtuin-1 and fasting glucose, BMI, and body weight (P<0.05).
Discussion and Conclusion: It appears that aerobic training improves insulin resistance in obese men with type 2 diabetes through increasing protein levels of sirtuin-1.
کلیدواژهها [English]
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