تأثیر هشت هفته تمرین هوازی و مصرف مکمل کوئرستین بر فشارخون، پروتئین واگنشگر- C، و اینترلوکین-6 زنان غیر فعال دارای اضافه وزن

نویسندگان

1 دانشگاه یزد

2 دانشگاه آزاد کرج

چکیده

مقدمه و هدف: یکی از عوارض اضافه‌وزن و چاقی التهاب و افزایش فشارخون است. هدف از پژوهش حاضر، بررسی تأثیر هشت هفته تمرین هوازی همراه با مصرف مکمل کوئرستین بر فشارخون، CRP < span lang="FA"> و IL-6 زنان غیرفعال دارای اضافه‌ وزن بود.
مواد و روش­ها: 40 زن سالم غیرفعال دارای اضافه‌ وزن (سن 6.1 ± 33.25 سال، درصد چربی 2.78 ± 36.65 و شاخص توده بدن 2.31 ± 28 کیلوگرم بر مترمربع) به 4 گروه مساوی تمرین + مکمل، تمرین + دارونما، مکمل و کنترل تقسیم شدند. برنامه تمرین هوازی شامل هشت هفته تمرین به‌صورت سه جلسه در هفته دویدن روی نوارگردان با شدت 80-65 درصد ضربان قلب بیشینه بود. برنامه مصرف مکمل کوئرستین یا دارونما روزانه 500 میلی­ گرم در روز بود. قبل و بعد از مداخله، شاخص­ های فشارخون سیستولیک (SBP < span lang="FA">)، دیاستولیک (DBP < span lang="FA">)، پروتئین واکنشگر-C و(CRP) و اینترلوکین-6 (IL-6) اندازه­ گیری شدند. داده ­ها با استفاده از آزمون کروسکال-والیس و ویلکاکسون در سطح معنی­ داری (0.05>P < span lang="FA">) تحلیل شدند.
یافته‌ها: نتایج نشان داد در مقایسه بین گروهی تفاوت معنی ­داری بین گروه‌ها وجود ندارد (0.05
). اما در مقایسه درون­ گروهی، مشخص شد شاخص­ های SBP < span lang="FA"> در تمامی گروه­ ها به‌ غیر از گروه کنترل، DBP < span lang="FA"> در گروه تمرین + مکمل و تمرین + دارونما، IL-6 در گروه مکمل، تمرین+ مکمل و تمرین + دارونما کاهش معنی­ داری داشتند (0.05>P < span lang="FA">). با وجود این، تفاوت معنی ­داری در مقادیر CRP گروه­ ها در مقایسه بین گروهی و درون ­گروهی مشاهده نشد (0.05).
بحث و نتیجه ­گیری: به نظر می­رسد تمرین هوازی با و بدون مصرف کوئرستین تا حدی می ­تواند برخی عوامل خطر بیماری‌های قلبی- عروقی زنان غیرفعال دارای اضافه‌وزن را کاهش دهد.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of eight weeks of aerobic training and Quercetin supplementation on blood pressure, C- reactive protein, and interleukin-6 in inactive overweight women

نویسندگان [English]

  • mohamadreza Sadeghian Shahi 1
  • zohreh bagherpour 2
  • Behzad Aria 1
  • farahnaz ayati zadeh 1
1
2
چکیده [English]

Introduction and purpose: One of the complications of overweight and obesity is inflammation and hypertension. This study aimed to evaluate the effect of eight weeks of aerobic training with quercetin supplementation on hypertension, CRP, and IL-6 in inactive overweight women.
Materials and Methods: Forty inactive healthy overweight women (age 33.25±6.1 years, fat percentage 36.65±2.78 and body mass index 28±2.31 kg/m2) were chosen and were divided into training + supplement (n=10), Training + placebo (n=10), supplement (n=10), and control (n=10). The aerobic training program consisted of eight weeks of running on a treadmill/three times per week, with an intensity of 65-80% of maximum heart rate. The quercetin or placebo supplement was 500 mg daily. Systolic blood pressure (SBP), diastolic blood pressure (DBP), C- reactive protein (CRP), and interleukin-6 (IL-6) were measured before and after the interventions. The data were analyzed by non-parametric Wilcoxon and Kruskal-Wallis Tests at the significance level of P<0.05. 
Results: The results showed that in the comparison between groups, there is no significant difference between any of the variables of the groups (P<0.05). But in the within-group comparison, it was found that the SBP indices in all groups except the control group, DBP in the exercise+supplement and exercise + placebo groups, IL-6 in the supplement, exercise + supplement and exercise + placebo­ groups had a significant decrease (P<0.05).However, no significant changes were observed in the CRP values ​​of the groups (P>0.05).
Discussion and Conclusion: It seems that aerobic exercise with and without quercetin consumption can partially reduce some risk factors of cardiovascular diseases in inactive overweight women.

 

کلیدواژه‌ها [English]

  • aerobic training
  • blood pressure
  • Quercetin Supplement
  • CRP
  • IL-6
1. Lanza GA, Golino M, Villano A, Lanza O, Lamendola P, Fusco A, et al. Cardiac Rehabilitation and Endothelial Function. J Clin Med. 2020; 9(8): 2487. 2. Garbers C, Heink S, Korn T, Rose-John S. Interleukin-6: designing specific therapeutics for a complex cytokine. Nat Rev Drug Discov. 2018; 17(6): 395-412. 3. Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018; 9: 754. 4. Escadafal C, Incardona S, Fernandez-Carballo BL, Dittrich S. The good and the bad: using C reactive protein to distinguish bacterial from non-bacterial infection among febrile patients in low-resource settings. BMJ Glob Health. 2020; 5(5): e002396. 5. Trapp EG, Chisholm DJ, Freund J, Boutcher SH. The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes (Lond). 2008; 32(4): 684-691. 6. Aria B, Parastesh M, Sadeghian Shahi M, Ayatizadeh Tafti F, Khavari Khorasani L. Rehabilitation for cardiovascular patients with Covid-19: A Review Study. Iranian Journal of Cardiovascular Nursing. 2020; 9(1): 234-242. 7. Gaeini AA, Fallahi AA, Kazemi F. Effects of aerobic continuous and interval training on rate-pressure product in patients after CABG surgery. J Sports Med Phys Fitness. 2015; 55(1-2): 76-83. 8. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta. 2010; 411(11-12): 785-793. 9. Salehi B, Machin L, Monzote L, Sharifi-Rad J, Ezzat SM, Salem MA, et al. Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health. ACS Omega. 2020; 5(20): 11849-11872. 10. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008; 585(2-3): 325-337. 11. Pereira SC, Parente JM, Belo VA, Mendes AS, Gonzaga NA, do Vale GT, et al. Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension. Atherosclerosis. 2018; 270: 146-153. 12. Tsao JP, Bernard JR, Hsu HC, Hsu CL, Liao SF, Cheng IS. Short-Term Oral Quercetin Supplementation Improves Post-exercise Insulin Sensitivity, Antioxidant Capacity and Enhances Subsequent Cycling Time to Exhaustion in Healthy Adults: A Pilot Study. Front Nutr. 2022; 9: 875319. 13. Häckl LP, Cuttle G, Dovichi SS, Lima-Landman MT, Nicolau M. Inhibition of angiotesin-converting enzyme by quercetin alters the vascular response to brandykinin and angiotensin I. Pharmacology. 2002; 65(4): 182-186. 14. Askari G, Ghiasvand R, Feizi A, Ghanadian SM, Karimian J. The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. J Res Med Sci. 2012; 17(7): 637-41. 15. Serban MC, Sahebkar A, Zanchetti A, Mikhailidis DP, Howard G, Antal D, et al. Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2016; 5(7): e002713. 16. Egert S, Bosy-Westphal A, Seiberl J, Kürbitz C, Settler U, Plachta-Danielzik S, et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr. 2009; 102(7): 1065-1074. 17. de Barcelos GT, Heberle I, Coneglian JC, Vieira BA, Delevatti RS, Gerage AM. Effects of Aerobic Training Progression on Blood Pressure in Individuals With Hypertension: A Systematic Review With Meta-Analysis and Meta-Regression. Front Sports Act Living. 2022; 4: 719063. 18. Christiansen T, Paulsen SK, Bruun JM, Pedersen SB, Richelsen B. Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: a 12-week randomized intervention study. Am J Physiol Endocrinol Metab. 2010; 298(4): E824-E831. 19. Libardi CA, De Souza GV, Cavaglieri CR, Madruga VA, Chacon-Mikahil MP. Effect of resistance, endurance, and concurrent training on TNF-α, IL-6, and CRP. Med Sci Sports Exerc. 2012; 44(1): 50-56. 20. Kaur S, Bansal Y, Kumar R, Bansal G. A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors. Bioorg Med Chem. 2020; 28(5): 115327. 21. Sellami M, Bragazzi NL, Aboghaba B, Elrayess MA. The Impact of Acute and Chronic Exercise on Immunoglobulins and Cytokines in Elderly: Insights From a Critical Review of the Literature. Front Immunol. 2021; 12: 631873. 22. García-Mediavilla V, Crespo I, Collado PS, Esteller A, Sánchez-Campos S, Tuñón MJ, et al. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007; 557(2-3): 221-229. 23. Nieman DC, Henson DA, Gross SJ, Jenkins DP, Davis J M, Murphy EA, et al. Quercetin reduces illness but not immune perturbations after intensive exercise. Med Sci Sports Exerc. 2007; 39(9): 1561-1569. 24. Gergerlioglu H ,Enver D,Muhammed A, Mehmet Oz. Effects of Quercetin in IL-6 and TNF-α Levels in Diabetic Rats.The faseb Journal. 2015; 29(1): 853-856. 25. Heidarian E, Amini A, Abbasi-Veldani A, Ghatreh-Samani K. Effects of Quercetin on Signaling Proteins (pSTAT3, pERK1/2, pAKT) and Interleukin-6 Gene Expression in Prostate Cancer PC3 cells. J Mazandaran Univ Med Sci. 2017; 26(144): 290-300. 26. Donges CE, Duffield R, Drinkwater EJ. Effects of resistance or aerobic exercise training on interleukin-6, C-reactive protein, and body composition. Med Sci Sports Exerc. 2010; 42(2): 304-313. 27. Daray LA, Henagan TM, Zanovec M, et al. Endurance and resistance training lowers C-reactive protein in young, healthy females. Appl Physiol Nutr Metab. 2011; 36(5): 660-670. 28. Makarewicz A, Jamka M, Geltz J, Śmidowicz A, Kokot M, Kaczmarek N, Mądry E, et al. Comparison of the Effect of Endurance, Strength, and Endurance-Strength Training on Inflammatory Markers and Adipokines Levels in Overweight and Obese Adults: Systematic Review and Meta-Analysis of Randomised Trials. Healthcare (Basel). 2022; 10(6): 1098 29. esema G, George M, Hadgu A, Haregot E, Mondal S, Mathivana D. Does chronic high-intensity endurance training have an effect on cardiovascular markers of active populations and athletes? Systematic review and meta-analysis. BMJ Open. 2019; 9(10): e032832. 30. Chun OK, Chung SJ, Claycombe KJ, Song WO. Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults. J Nutr. 2008; 138(4): 753-760.